Use of low-frequency electrical impedance measurements to determine phospholipid content in amniotic fluid

F. De Luca, C. Cametti, G. Zimatore, B. Maraviglia, A. Pachi'

Research output: Contribution to journalArticlepeer-review

Abstract

In this report we propose a new method for an in vitro test of the foetal lung maturity based on the measurement of the electrical conductivity of the overall amniotic fluid obtained from transabdominal amniocentesis, since this quantity can be linked to a first approximation in a very simple way to the phospholipid content. We have carried out measurements of 85 different samples of amniotic fluid as a function of gestation weeks and we have observed a pronounced change of the electrical conductivity that reflects the increase in the phospholipid concentration occurring at the end of normal pregnancies. The method could be further developed to obtain similar information on in vivo experiments by means of bioelectric impedance tomography, taking advantage of the frequency dependence of the tissue electrical impedance.

Original languageEnglish
Pages (from-to)1863-1869
Number of pages7
JournalPhysics in Medicine and Biology
Volume41
Issue number9
DOIs
Publication statusPublished - Sep 1996

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physics and Astronomy (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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