Use of monoclonal antibodies to human breast-tumor-associated antigens in fine-needle aspirate cytology

M. Nuti, M. Mottolese, M. Viora, R. P. Donnorso, J. Schlom, P. G. Natali

Research output: Contribution to journalArticlepeer-review

Abstract

Fine-needle aspiration cytology (FNAC) is currently used in evaluating the nature of breast nodules. In the present study we have examined whether monoclonal antibodies (MAbs) to breast-tumor-associated antigens (BTAA) can be employed in FNAC for the diagnosis of breast cancer. For this purpose we have used 2 murine MAbs recognizing 2 distinct BTAA expressed by breast tumors, irrespective of their histotype, in an indirect avidin-biotin immunohistochemical technique on aspirate smears. The results of this study show that, while benign lesions are consistently negative, tumor cells containing aspirates are reactive with at least one MAb in 95% of the cases. Thus, selected MAbs to BTAA may be a powerful diagnostic tool in conjunction with conventional cytology, and because of the objective interpretation of the immunohistochemical findings, FNAC of the breast can eventually be extended outside specialized institutions.

Original languageEnglish
Pages (from-to)493-498
Number of pages6
JournalInternational Journal of Cancer
Volume37
Issue number4
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'Use of monoclonal antibodies to human breast-tumor-associated antigens in fine-needle aspirate cytology'. Together they form a unique fingerprint.

Cite this