Use of monoclonal antibodies to human breast-tumor-associated antigens in the diagnosis of fine-needle aspirates of breast nodules: Results of a multicenter study

P. G. Natali, M. Mottolese, R. Perrone Donnorso, R. Buffa, G. Bussolati, G. Coggi, G. Corradi, L. Coscia-Porrazzi, M. Ferretti, E. Rondanelli, M. Castagna, A. Vecchione, G. A. Siccardi

Research output: Contribution to journalArticle

Abstract

Fine-needle aspiration (FNA) cytology is being increasingly employed in conjunction with physical examination and mammography in the pre-surgical diagnosis of breast nodules. In the present study, we have submitted to multicenter validation an immunocytochemical test which employs monoclonal antibodies (MAbs) to breast-tumor-associated antigens (BTAA) for the diagnosis of breast cancer. The results of this analysis, which has evaluated 846 FNAs, show that the immunological test has a sensitivity of 88.62%, a specificity of 97.9% and an accuracy of 92.4%. The predictive value of a positive and a negative finding were 98.4% and 85.57% respectively. Comparison between the cytological and immunocytochemical diagnosis displayed a higher sensitivity, accuracy and predictive value of a negative result with the latter method (p <0.01). Our findings clearly indicate that immunocytochemical methods can complement and improve the diagnostic accuracy of FNA cytology of breast nodules.

Original languageEnglish
Pages (from-to)12-15
Number of pages4
JournalInternational Journal of Cancer
Volume45
Issue number1
DOIs
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Natali, P. G., Mottolese, M., Perrone Donnorso, R., Buffa, R., Bussolati, G., Coggi, G., Corradi, G., Coscia-Porrazzi, L., Ferretti, M., Rondanelli, E., Castagna, M., Vecchione, A., & Siccardi, G. A. (1990). Use of monoclonal antibodies to human breast-tumor-associated antigens in the diagnosis of fine-needle aspirates of breast nodules: Results of a multicenter study. International Journal of Cancer, 45(1), 12-15. https://doi.org/10.1002/ijc.2910450104