Use of monoclonal antibodies to human breast-tumor-associated antigens in the diagnosis of fine-needle aspirates of breast nodules: Results of a multicenter study

P. G. Natali, M. Mottolese, R. Perrone Donnorso, R. Buffa, G. Bussolati, G. Coggi, G. Corradi, L. Coscia-Porrazzi, M. Ferretti, E. Rondanelli, M. Castagna, A. Vecchione, G. A. Siccardi

Research output: Contribution to journalArticle

Abstract

Fine-needle aspiration (FNA) cytology is being increasingly employed in conjunction with physical examination and mammography in the pre-surgical diagnosis of breast nodules. In the present study, we have submitted to multicenter validation an immunocytochemical test which employs monoclonal antibodies (MAbs) to breast-tumor-associated antigens (BTAA) for the diagnosis of breast cancer. The results of this analysis, which has evaluated 846 FNAs, show that the immunological test has a sensitivity of 88.62%, a specificity of 97.9% and an accuracy of 92.4%. The predictive value of a positive and a negative finding were 98.4% and 85.57% respectively. Comparison between the cytological and immunocytochemical diagnosis displayed a higher sensitivity, accuracy and predictive value of a negative result with the latter method (p <0.01). Our findings clearly indicate that immunocytochemical methods can complement and improve the diagnostic accuracy of FNA cytology of breast nodules.

Original languageEnglish
Pages (from-to)12-15
Number of pages4
JournalInternational Journal of Cancer
Volume45
Issue number1
DOIs
Publication statusPublished - 1990

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Neoplasm Antigens
Multicenter Studies
Needles
Breast
Monoclonal Antibodies
Breast Neoplasms
Fine Needle Biopsy
Cell Biology
Immunologic Tests
Mammography
Physical Examination

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Use of monoclonal antibodies to human breast-tumor-associated antigens in the diagnosis of fine-needle aspirates of breast nodules : Results of a multicenter study. / Natali, P. G.; Mottolese, M.; Perrone Donnorso, R.; Buffa, R.; Bussolati, G.; Coggi, G.; Corradi, G.; Coscia-Porrazzi, L.; Ferretti, M.; Rondanelli, E.; Castagna, M.; Vecchione, A.; Siccardi, G. A.

In: International Journal of Cancer, Vol. 45, No. 1, 1990, p. 12-15.

Research output: Contribution to journalArticle

Natali, PG, Mottolese, M, Perrone Donnorso, R, Buffa, R, Bussolati, G, Coggi, G, Corradi, G, Coscia-Porrazzi, L, Ferretti, M, Rondanelli, E, Castagna, M, Vecchione, A & Siccardi, GA 1990, 'Use of monoclonal antibodies to human breast-tumor-associated antigens in the diagnosis of fine-needle aspirates of breast nodules: Results of a multicenter study', International Journal of Cancer, vol. 45, no. 1, pp. 12-15. https://doi.org/10.1002/ijc.2910450104
Natali, P. G. ; Mottolese, M. ; Perrone Donnorso, R. ; Buffa, R. ; Bussolati, G. ; Coggi, G. ; Corradi, G. ; Coscia-Porrazzi, L. ; Ferretti, M. ; Rondanelli, E. ; Castagna, M. ; Vecchione, A. ; Siccardi, G. A. / Use of monoclonal antibodies to human breast-tumor-associated antigens in the diagnosis of fine-needle aspirates of breast nodules : Results of a multicenter study. In: International Journal of Cancer. 1990 ; Vol. 45, No. 1. pp. 12-15.
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