Use of N-acetylcysteine in the management of coronary artery diseases.

G. Marchetti, E. Lodola, L. Licciardello, A. Colombo

Research output: Contribution to journalReview articlepeer-review


Thrombolysis after acute myocardial infarction may lead to a number of adverse effects (reperfusion injury) such as myocardial stunning, arrhythmias and even myocardial damage and extension of the infarct size. Some recent clinical studies have demonstrated that the intravenous infusion of N-acetylcysteine during thrombolysis was associated with a decrease in infarct size and better preservation of left ventricular function, probably due to antioxidant and free radical scavenger properties of N-acetylcysteine. Short- and long-term studies indicated that also in patients with unstable angina pectoris and threat of infarct, the intravenous or oral administration of N-acetylcysteine in association with nitroglycerin is highly effective in decreasing the risk of worsening, mainly by preventing the occurrence of acute myocardial infarction.

Original languageEnglish
Pages (from-to)633-637
Number of pages5
Issue number7
Publication statusPublished - Jul 1999

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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