Use of neck magnetic resonance venography, Doppler sonography and selective venography for diagnosis of chronic cerebrospinal venous insufficiency: A pilot study in multiple sclerosis patients and healthy controls

D. Hojnacki, P. Zamboni, A. Lopez-Soriano, R. Galleotti, E. Menegatti, B. Weinstock-Guttman, C. Schirda, C. Magnano, A. M. Malagoni, C. Kennedy, I. Bartolomei, F. Salvi, R. Zivadinov

Research output: Contribution to journalArticle

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Abstract

Aim. Chronic cerebrospinal venous insufficiency (CCSVI) is a vascular condition characterized by anomalies of primary veins outside the skull that restrict normal outflow of blood from the brain. CCSVI was recently described as highly prevalent in patients with multiple sclerosis (MS), and can be non-invasively diagnosed by Doppler sonography (DS) and invasively by selective venography (SV). The aim of this paper was to investigate the value of neck magnetic resonance venography (MRV) for the diagnosis of CCSVI compared to DS and SV in patients with MS and in healthy controls (HC). Methods. Ten MS patients and 7 HC underwent DS, 2D-Time-Of-Flight venography (TOF) and 3D-Time Resolved Imaging of Contrast Kinetics angiography (TRICKS). MS patients also underwent SV. The internal jugular veins (IJVs) and the vertebral veins (VVs) were assessed by both MRV sequences, and the findings were validated against SV and DS. SV has been considered the diagnostic gold standard for MS patients. Results. All MS patients and none of the HC presented CCSVI, according to the DS criteria. This was confirmed by SV. For CCSVI diagnosis, DS showed sensitivity, specificity, accuracy, PPV and NPV of 100%, whereas the figures were 40%, 85%, 58%, 80% and 50% for 3D-TRICKS, and 30%, 85%, 52%, 75% and 46% for 2D-TOF in the IJVs. In MS patients, compared to SV, DS showed sensitivity, specificity, accuracy, PPV and NPV of 100%, 75%, 95%, 94% and 100%, whereas the figures were 31%, 100%, 45%, 100% and 26% for 3D-TRICKS and 25%, 100%, 40%, 100% and 25% for 2D-TOF in the IJVs. Conclusion. The use of MRV for diagnosis of CCSVI in MS patients has limited value, and the findings should be interpreted with caution and confirmed by other imaging techniques such as DS and SV.

Original languageEnglish
Pages (from-to)127-139
Number of pages13
JournalInternational Angiology
Volume29
Issue number2
Publication statusPublished - Apr 2010

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Doppler Ultrasonography
Venous Insufficiency
Phlebography
Multiple Sclerosis
Neck
Magnetic Resonance Spectroscopy
Jugular Veins
Angiography
Veins
Sensitivity and Specificity
Skull

Keywords

  • Magnetic resonance imaging
  • Multiple sclerosis
  • Ultrasonography
  • Venography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Use of neck magnetic resonance venography, Doppler sonography and selective venography for diagnosis of chronic cerebrospinal venous insufficiency : A pilot study in multiple sclerosis patients and healthy controls. / Hojnacki, D.; Zamboni, P.; Lopez-Soriano, A.; Galleotti, R.; Menegatti, E.; Weinstock-Guttman, B.; Schirda, C.; Magnano, C.; Malagoni, A. M.; Kennedy, C.; Bartolomei, I.; Salvi, F.; Zivadinov, R.

In: International Angiology, Vol. 29, No. 2, 04.2010, p. 127-139.

Research output: Contribution to journalArticle

Hojnacki, D, Zamboni, P, Lopez-Soriano, A, Galleotti, R, Menegatti, E, Weinstock-Guttman, B, Schirda, C, Magnano, C, Malagoni, AM, Kennedy, C, Bartolomei, I, Salvi, F & Zivadinov, R 2010, 'Use of neck magnetic resonance venography, Doppler sonography and selective venography for diagnosis of chronic cerebrospinal venous insufficiency: A pilot study in multiple sclerosis patients and healthy controls', International Angiology, vol. 29, no. 2, pp. 127-139.
Hojnacki, D. ; Zamboni, P. ; Lopez-Soriano, A. ; Galleotti, R. ; Menegatti, E. ; Weinstock-Guttman, B. ; Schirda, C. ; Magnano, C. ; Malagoni, A. M. ; Kennedy, C. ; Bartolomei, I. ; Salvi, F. ; Zivadinov, R. / Use of neck magnetic resonance venography, Doppler sonography and selective venography for diagnosis of chronic cerebrospinal venous insufficiency : A pilot study in multiple sclerosis patients and healthy controls. In: International Angiology. 2010 ; Vol. 29, No. 2. pp. 127-139.
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abstract = "Aim. Chronic cerebrospinal venous insufficiency (CCSVI) is a vascular condition characterized by anomalies of primary veins outside the skull that restrict normal outflow of blood from the brain. CCSVI was recently described as highly prevalent in patients with multiple sclerosis (MS), and can be non-invasively diagnosed by Doppler sonography (DS) and invasively by selective venography (SV). The aim of this paper was to investigate the value of neck magnetic resonance venography (MRV) for the diagnosis of CCSVI compared to DS and SV in patients with MS and in healthy controls (HC). Methods. Ten MS patients and 7 HC underwent DS, 2D-Time-Of-Flight venography (TOF) and 3D-Time Resolved Imaging of Contrast Kinetics angiography (TRICKS). MS patients also underwent SV. The internal jugular veins (IJVs) and the vertebral veins (VVs) were assessed by both MRV sequences, and the findings were validated against SV and DS. SV has been considered the diagnostic gold standard for MS patients. Results. All MS patients and none of the HC presented CCSVI, according to the DS criteria. This was confirmed by SV. For CCSVI diagnosis, DS showed sensitivity, specificity, accuracy, PPV and NPV of 100{\%}, whereas the figures were 40{\%}, 85{\%}, 58{\%}, 80{\%} and 50{\%} for 3D-TRICKS, and 30{\%}, 85{\%}, 52{\%}, 75{\%} and 46{\%} for 2D-TOF in the IJVs. In MS patients, compared to SV, DS showed sensitivity, specificity, accuracy, PPV and NPV of 100{\%}, 75{\%}, 95{\%}, 94{\%} and 100{\%}, whereas the figures were 31{\%}, 100{\%}, 45{\%}, 100{\%} and 26{\%} for 3D-TRICKS and 25{\%}, 100{\%}, 40{\%}, 100{\%} and 25{\%} for 2D-TOF in the IJVs. Conclusion. The use of MRV for diagnosis of CCSVI in MS patients has limited value, and the findings should be interpreted with caution and confirmed by other imaging techniques such as DS and SV.",
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T1 - Use of neck magnetic resonance venography, Doppler sonography and selective venography for diagnosis of chronic cerebrospinal venous insufficiency

T2 - A pilot study in multiple sclerosis patients and healthy controls

AU - Hojnacki, D.

AU - Zamboni, P.

AU - Lopez-Soriano, A.

AU - Galleotti, R.

AU - Menegatti, E.

AU - Weinstock-Guttman, B.

AU - Schirda, C.

AU - Magnano, C.

AU - Malagoni, A. M.

AU - Kennedy, C.

AU - Bartolomei, I.

AU - Salvi, F.

AU - Zivadinov, R.

PY - 2010/4

Y1 - 2010/4

N2 - Aim. Chronic cerebrospinal venous insufficiency (CCSVI) is a vascular condition characterized by anomalies of primary veins outside the skull that restrict normal outflow of blood from the brain. CCSVI was recently described as highly prevalent in patients with multiple sclerosis (MS), and can be non-invasively diagnosed by Doppler sonography (DS) and invasively by selective venography (SV). The aim of this paper was to investigate the value of neck magnetic resonance venography (MRV) for the diagnosis of CCSVI compared to DS and SV in patients with MS and in healthy controls (HC). Methods. Ten MS patients and 7 HC underwent DS, 2D-Time-Of-Flight venography (TOF) and 3D-Time Resolved Imaging of Contrast Kinetics angiography (TRICKS). MS patients also underwent SV. The internal jugular veins (IJVs) and the vertebral veins (VVs) were assessed by both MRV sequences, and the findings were validated against SV and DS. SV has been considered the diagnostic gold standard for MS patients. Results. All MS patients and none of the HC presented CCSVI, according to the DS criteria. This was confirmed by SV. For CCSVI diagnosis, DS showed sensitivity, specificity, accuracy, PPV and NPV of 100%, whereas the figures were 40%, 85%, 58%, 80% and 50% for 3D-TRICKS, and 30%, 85%, 52%, 75% and 46% for 2D-TOF in the IJVs. In MS patients, compared to SV, DS showed sensitivity, specificity, accuracy, PPV and NPV of 100%, 75%, 95%, 94% and 100%, whereas the figures were 31%, 100%, 45%, 100% and 26% for 3D-TRICKS and 25%, 100%, 40%, 100% and 25% for 2D-TOF in the IJVs. Conclusion. The use of MRV for diagnosis of CCSVI in MS patients has limited value, and the findings should be interpreted with caution and confirmed by other imaging techniques such as DS and SV.

AB - Aim. Chronic cerebrospinal venous insufficiency (CCSVI) is a vascular condition characterized by anomalies of primary veins outside the skull that restrict normal outflow of blood from the brain. CCSVI was recently described as highly prevalent in patients with multiple sclerosis (MS), and can be non-invasively diagnosed by Doppler sonography (DS) and invasively by selective venography (SV). The aim of this paper was to investigate the value of neck magnetic resonance venography (MRV) for the diagnosis of CCSVI compared to DS and SV in patients with MS and in healthy controls (HC). Methods. Ten MS patients and 7 HC underwent DS, 2D-Time-Of-Flight venography (TOF) and 3D-Time Resolved Imaging of Contrast Kinetics angiography (TRICKS). MS patients also underwent SV. The internal jugular veins (IJVs) and the vertebral veins (VVs) were assessed by both MRV sequences, and the findings were validated against SV and DS. SV has been considered the diagnostic gold standard for MS patients. Results. All MS patients and none of the HC presented CCSVI, according to the DS criteria. This was confirmed by SV. For CCSVI diagnosis, DS showed sensitivity, specificity, accuracy, PPV and NPV of 100%, whereas the figures were 40%, 85%, 58%, 80% and 50% for 3D-TRICKS, and 30%, 85%, 52%, 75% and 46% for 2D-TOF in the IJVs. In MS patients, compared to SV, DS showed sensitivity, specificity, accuracy, PPV and NPV of 100%, 75%, 95%, 94% and 100%, whereas the figures were 31%, 100%, 45%, 100% and 26% for 3D-TRICKS and 25%, 100%, 40%, 100% and 25% for 2D-TOF in the IJVs. Conclusion. The use of MRV for diagnosis of CCSVI in MS patients has limited value, and the findings should be interpreted with caution and confirmed by other imaging techniques such as DS and SV.

KW - Magnetic resonance imaging

KW - Multiple sclerosis

KW - Ultrasonography

KW - Venography

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