Use of polymerase chain reaction nad denaturing gradient gel electrophoresis to identify polymorphisms in three exons of dopamine D2 receptor gene in schizophrenic and delusional patients

Marco Catalano; Maria Nobile; Emanuela Novelli; Enrico Smeraldi

doi:10.1159/000118888

Use of polymerase chain reaction nad denaturing gradient gel electrophoresis to identify polymorphisms in three exons of dopamine D₂ receptor gene in schizophrenic and delusional patients

Marco Catalano, Maria Nobile, Emanuela Novelli, Enrico Smeraldi

Research output: Contribution to journal › Article › peer-review

Abstract

The dopamine D₂ receptor gene is a candidate gene for schizophrenia. We screened three exons of this gene for mutations in a large sample of schizophrenics. delusional patients and healthy controls. No structural changes were found, thus suggesting that psychopathology is not related to DNA alterations in the DRD₂ gene.

Original language	English
Pages (from-to)	1-3
Number of pages	3
Journal	Neuropsychobiology
Volume	26
Issue number	1-2
DOIs	https://doi.org/10.1159/000118888
Publication status	Published - 1992

Keywords

Delusional disorder
Denaturing gradient gel electrophoresis
DNA
Dopamine D<inf>2</inf> receptor gene
Polymerase chain reaction
Polymorphisms
Schizophrenia

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry
Neuropsychology and Physiological Psychology
Neuroscience(all)
Psychology(all)

Access to Document

10.1159/000118888

Cite this

Use of polymerase chain reaction nad denaturing gradient gel electrophoresis to identify polymorphisms in three exons of dopamine D₂ receptor gene in schizophrenic and delusional patients. / Catalano, Marco; Nobile, Maria; Novelli, Emanuela; Smeraldi, Enrico.

In: Neuropsychobiology, Vol. 26, No. 1-2, 1992, p. 1-3.

Research output: Contribution to journal › Article › peer-review

@article{05df1601d06d4c0d88100b35d568a1ed,

title = "Use of polymerase chain reaction nad denaturing gradient gel electrophoresis to identify polymorphisms in three exons of dopamine D2 receptor gene in schizophrenic and delusional patients",

abstract = "The dopamine D2 receptor gene is a candidate gene for schizophrenia. We screened three exons of this gene for mutations in a large sample of schizophrenics. delusional patients and healthy controls. No structural changes were found, thus suggesting that psychopathology is not related to DNA alterations in the DRD2 gene.",

keywords = "Delusional disorder, Denaturing gradient gel electrophoresis, DNA, Dopamine D<inf>2</inf> receptor gene, Polymerase chain reaction, Polymorphisms, Schizophrenia",

author = "Marco Catalano and Maria Nobile and Emanuela Novelli and Enrico Smeraldi",

year = "1992",

doi = "10.1159/000118888",

language = "English",

volume = "26",

pages = "1--3",

journal = "Neuropsychobiology",

issn = "0302-282X",

publisher = "S. Karger AG",

number = "1-2",

}

TY - JOUR

T1 - Use of polymerase chain reaction nad denaturing gradient gel electrophoresis to identify polymorphisms in three exons of dopamine D2 receptor gene in schizophrenic and delusional patients

AU - Catalano, Marco

AU - Nobile, Maria

AU - Novelli, Emanuela

AU - Smeraldi, Enrico

PY - 1992

Y1 - 1992

N2 - The dopamine D2 receptor gene is a candidate gene for schizophrenia. We screened three exons of this gene for mutations in a large sample of schizophrenics. delusional patients and healthy controls. No structural changes were found, thus suggesting that psychopathology is not related to DNA alterations in the DRD2 gene.

AB - The dopamine D2 receptor gene is a candidate gene for schizophrenia. We screened three exons of this gene for mutations in a large sample of schizophrenics. delusional patients and healthy controls. No structural changes were found, thus suggesting that psychopathology is not related to DNA alterations in the DRD2 gene.

KW - Delusional disorder

KW - Denaturing gradient gel electrophoresis

KW - DNA

KW - Dopamine D<inf>2</inf> receptor gene

KW - Polymerase chain reaction

KW - Polymorphisms

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=0026539994&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026539994&partnerID=8YFLogxK

U2 - 10.1159/000118888

DO - 10.1159/000118888

M3 - Article

C2 - 1475034

AN - SCOPUS:0026539994

VL - 26

SP - 1

EP - 3

JO - Neuropsychobiology

JF - Neuropsychobiology

SN - 0302-282X

IS - 1-2

ER -