Use of probiotics in medical devices applied to some common pathologies

Maria Verrucci, Angelo Iacobino, Lanfranco Fattorini, Roberta Marcoaldi, Antonino Maggio, Giovanni Piccaro

Research output: Contribution to journalReview articlepeer-review


Probiotics, defined as "living microorganisms that, whether ingested in useful amount, may have beneficial effects on human body", are widely used in various products for human use, such as dietary supplements, medical devices and pharmaceutical products. The European Directive on medical devices (MDs) (DDM 93/42), also includes those MDs containing live microorganisms, particularly probiotics, that may have various destinations of use, including that of assisting the therapy of several human pathologies. In this brief note we analyzed the use of probiotics in MDs and how probiotics administration could represent one of the new frontiers of scientific research on the prevention and treatment of various diseases. We'll analyze the literature on probiotics based MDs, to review their major targets in the therapy of some of the most common human pathologies: bacterial vaginosis and vaginitis, atopic dermatitis, infantile colic, obesity, type 2 diabetes, and pharyngotonsillitis.

Original languageEnglish
Pages (from-to)380-385
Number of pages6
JournalAnnali dell'Istituto Superiore di Sanita
Issue number4
Publication statusPublished - Dec 19 2019


  • Administration, Oral
  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Colic/therapy
  • Dermatitis, Atopic
  • Diabetes Mellitus, Type 2/therapy
  • Double-Blind Method
  • Equipment and Supplies/microbiology
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Lactobacillus
  • Male
  • Obesity/prevention & control
  • Pharyngitis/therapy
  • Prebiotics/administration & dosage
  • Probiotics/administration & dosage
  • Randomized Controlled Trials as Topic
  • Suppositories
  • Synbiotics/administration & dosage
  • Tonsillitis/therapy
  • Vaginitis/microbiology
  • Vaginosis, Bacterial/microbiology


Dive into the research topics of 'Use of probiotics in medical devices applied to some common pathologies'. Together they form a unique fingerprint.

Cite this