IMPIEGO DELL'ARTERIA POLMONARE PER L'INFUSIONE DI ANTIBLASTICI NELL'AMBITO DI TRATTAMENTI MULTIMODALI DELLE METASTASI POLMONARI

Translated title of the contribution: Use of pulmonary artery for antineoplastic agent, infusion in the treatment of multiple pulmonary metastases

G. B. Ratto, G. Fantino, E. Tassara, S. Bondi, A. Catrullo, L. Raco, F. Trevisan, D. Gianquinto, F. Simonetti

Research output: Contribution to journalArticle

Abstract

The treatment of multiple pulmonary metastases is generally based on the combined application of chemotherapy and surgery. For such a multimodality approach, antineoplastic agent infusion through the pulmonary artery might afford significant advantages, with respect to the systemic administration route. In order to verify this assumption, a standard dose of cisplatin (2.5 mg/kg) was given to 12 pigs through a peripheral vein or the pulmonary artery (with or without stop-flow and out-flow occlusion). During 4 hours following infusion, serial samples of blood (peripheral and pulmonary), lung and mediastinal nodes were taken. Specimens from major organs were then obtained. Platinum concentrations in plasma and tissues were measured by spectroscopy. Pulmonary artery infusion, even when delivered using the stop-flow technique, yielded no consistent pharmacokinetic advantage over peripheral vein administration. Instead, pulmonary artery infusion with stop-flow and out-flow occlusion was highly effective in increasing local concentrations of drug, while reducing its systemic levels.

Translated title of the contributionUse of pulmonary artery for antineoplastic agent, infusion in the treatment of multiple pulmonary metastases
Original languageItalian
Pages (from-to)685-690
Number of pages6
JournalChirurgia
Volume4
Issue number12
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Surgery

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    Ratto, G. B., Fantino, G., Tassara, E., Bondi, S., Catrullo, A., Raco, L., Trevisan, F., Gianquinto, D., & Simonetti, F. (1991). IMPIEGO DELL'ARTERIA POLMONARE PER L'INFUSIONE DI ANTIBLASTICI NELL'AMBITO DI TRATTAMENTI MULTIMODALI DELLE METASTASI POLMONARI. Chirurgia, 4(12), 685-690.