The treatment of multiple pulmonary metastases is generally based on the combined application of chemotherapy and surgery. For such a multimodality approach, antineoplastic agent infusion through the pulmonary artery might afford significant advantages, with respect to the systemic administration route. In order to verify this assumption, a standard dose of cisplatin (2.5 mg/kg) was given to 12 pigs through a peripheral vein or the pulmonary artery (with or without stop-flow and out-flow occlusion). During 4 hours following infusion, serial samples of blood (peripheral and pulmonary), lung and mediastinal nodes were taken. Specimens from major organs were then obtained. Platinum concentrations in plasma and tissues were measured by spectroscopy. Pulmonary artery infusion, even when delivered using the stop-flow technique, yielded no consistent pharmacokinetic advantage over peripheral vein administration. Instead, pulmonary artery infusion with stop-flow and out-flow occlusion was highly effective in increasing local concentrations of drug, while reducing its systemic levels.
|Translated title of the contribution||Use of pulmonary artery for antineoplastic agent, infusion in the treatment of multiple pulmonary metastases|
|Number of pages||6|
|Publication status||Published - 1991|
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