Pyridoxine-alpha-ketoglutarate (PAK) was administered to patients with high blood ammonia levels and with clinical signs of hepatic encephalopathy (HE). Plasma concentrations of ammonia decreased and clinical symptomatology improved. The activity of PAK was greater than that of lactulose in lowering blood ammonia levels but not significantly different in its relief of neuropsychic symptoms.
|Number of pages||7|
|Journal||International Journal of Clinical Pharmacology Research|
|Issue number||4 Suppl. 1|
|Publication status||Published - 1982|
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)