Use of read-across tools

Serena Manganelli, Emilio Benfenati

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Read-across has become popular since the introduction of regulations, such as the European REACH regulation. This chapter provides instructions on how to use ToxRead, new freely available software for read-across analysis, and on how to interpret its output predictions for mutagenicity assessments. This tool offers two seminal sources: a set of rules/structural alerts, which may explain the toxicity, and a similarity tool, associated with a large database of chemicals with their properties.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages305-322
Number of pages18
Volume1425
DOIs
Publication statusPublished - 2016

Publication series

NameMethods in Molecular Biology
Volume1425
ISSN (Print)10643745

Keywords

  • Mutagenicity
  • REACH
  • Read-across
  • Rules
  • SAR
  • Structural alerts
  • ToxRead

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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  • Cite this

    Manganelli, S., & Benfenati, E. (2016). Use of read-across tools. In Methods in Molecular Biology (Vol. 1425, pp. 305-322). (Methods in Molecular Biology; Vol. 1425). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-3609-0_13