Use of read-across tools

Serena Manganelli, Emilio Benfenati

Research output: Chapter in Book/Report/Conference proceedingChapter


Read-across has become popular since the introduction of regulations, such as the European REACH regulation. This chapter provides instructions on how to use ToxRead, new freely available software for read-across analysis, and on how to interpret its output predictions for mutagenicity assessments. This tool offers two seminal sources: a set of rules/structural alerts, which may explain the toxicity, and a similarity tool, associated with a large database of chemicals with their properties.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages18
Publication statusPublished - 2016

Publication series

NameMethods in Molecular Biology
ISSN (Print)10643745


  • Mutagenicity
  • Read-across
  • Rules
  • SAR
  • Structural alerts
  • ToxRead

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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