Use of Skin Biopsy in the Diagnosis of Small Fibre Neuropathy

G. Lauria, S. T. Hsieh, O. Johansson, W. R. Kennedy, J. M. Leger, S. I. Mellgren, M. Nolano, I. S J Merkies, M. Polydefkis, A. G. Smith, C. Sommer, J. Valls-Solé

Research output: Chapter in Book/Report/Conference proceedingChapter

Original languageEnglish
Title of host publicationEuropean Handbook of Neurological Management: Second Edition
Number of pages10
ISBN (Print)9781405185332
Publication statusPublished - Sep 6 2010


  • Clinical applications of skin biopsy in SFN-using similar inclusion criteria for patients
  • Correlation with small fibre-related evoked potentials
  • Data extraction, carried out-and compared among each member of task force
  • Document, written under auspices of European Federation of the Neurological Societies (EFNS)
  • IENF morphometry and measurement reliability
  • Less invasive sampling method-removal of epidermis alone by applying a suction capsule to skin
  • Normative reference values-Bright-field immunohistochemistry
  • Perform skin biopsy and choice of biopsy location
  • Quantification of sweat gland innervation
  • Skin biopsy use-in diagnosis of small fibre neuropathy

ASJC Scopus subject areas

  • Neuroscience(all)

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