Use of testosterone gel compared to intramuscular formulation for puberty induction in males with constitutional delay of growth and puberty: a preliminary study

Laura Chioma, Giulia Papucci, Danilo Fintini, Marco Cappa

Research output: Contribution to journalArticle

Abstract

Purpose: Constitutional delay of growth and puberty (CDGP) treatment include observation or therapy with intramuscular testosterone (IMTT). No data are available about transdermal testosterone gel (TTG). The aim of our study was to analyze the use of TTG in males with CDGP. Methods: 73 boys with CDGP were divided into three groups: IMTT treated with 50 mg i.m. testosterone; TTG with 10 mg daily 2% testosterone transdermal gel, and no treatment (CNT). All subjects were observed at baseline and after 6 months. Results: The height velocity after treatment were statistically higher in both IMTT and TTG compared to CNT, while CNT showed higher increase of the testicular volume. No other differences were recorded between IMTT and TTG. Conclusions: To our knowledge this is the first study on use of TTG for pubertal activation on CDGP population. Our preliminary data confirm the efficacy of short-term Testosterone gel treatment to induce puberty compared to conventional treatment.

Original languageEnglish
Pages (from-to)259-263
Number of pages5
JournalJournal of Endocrinological Investigation
Volume41
Issue number2
DOIs
Publication statusPublished - Jul 10 2017

Keywords

  • Adolescents
  • Constitutional delay of growth and puberty
  • Puberty induction
  • Transdermal testosterone gel

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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