Use of the platelet count/spleen diameter ratio for the noninvasive diagnosis of esophageal varices in patients with schistosomiasis

Adnan Agha, Mamdouh Abdulhadi, Simona Marenco, Abdelhaleem Bella, Dib Alsaudi, Ahmed El-Haddad, Simona Inferrera, Vincenzo Savarino, Edoardo Giannini

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background/Aim: In patients with liver cirrhosis, the platelet count/spleen diameter ratio has been validated as a parameter for the noninvasive diagnosis of esophageal varices. Schistosoma infection is a frequent cause of portal hypertension in Middle Eastern countries, and is associated with the development of esophageal varices. In this study we aimed to evaluate the platelet count/spleen diameter ratio as a noninvasive tool for the prediction of the presence of esophageal varices in patients with schistosoma-related chronic liver disease. Patients and Methods: Forty-three patients with hepatosplenic schistosomiasis underwent upper digestive endoscopy to check for the presence of esophageal varices. Furthermore, all patients underwent abdominal ultrasonography, and maximum spleen diameter (in mm) was measured. The platelet count/spleen diameter ratio was calculated in all patients. Results: Esophageal varices were found in 31 patients (72%). Age and gender were not significantly different between patients with and without varices. In patients with varices, median platelet count (82,000/L versus 172,000/L, P <0.0001) and platelet count/spleen diameter ratio (571 versus 1651, P <0.0001) were significantly lower, while spleen diameter (147 mm versus 109 mm, P = 0.0006) was significantly larger. In multivariate analysis, the platelet count/spleen diameter ratio was the only parameter independently associated with the presence of varices (P <0.0001). Conclusions: In this study we have validated the use of the platelet count/spleen diameter ratio for the noninvasive diagnosis of esophageal varices in patients with portal hypertension caused by schistosoma infection. In these patients, the platelet count/spleen diameter ratio might be used to allow better rationalization of medical resources and use of endoscopy.

Original languageEnglish
Pages (from-to)307-311
Number of pages5
JournalSaudi Journal of Gastroenterology
Volume17
Issue number5
DOIs
Publication statusPublished - Sep 2011

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Esophageal and Gastric Varices
Schistosomiasis
Platelet Count
Spleen
Schistosoma
Varicose Veins
Portal Hypertension
Endoscopy
Infection
Liver Cirrhosis
Liver Diseases
Ultrasonography
Chronic Disease
Multivariate Analysis

Keywords

  • Esophageal varices
  • noninvasive
  • platelet count/spleen diameter ratio
  • portal hypertension
  • schistosomiasis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Use of the platelet count/spleen diameter ratio for the noninvasive diagnosis of esophageal varices in patients with schistosomiasis. / Agha, Adnan; Abdulhadi, Mamdouh; Marenco, Simona; Bella, Abdelhaleem; Alsaudi, Dib; El-Haddad, Ahmed; Inferrera, Simona; Savarino, Vincenzo; Giannini, Edoardo.

In: Saudi Journal of Gastroenterology, Vol. 17, No. 5, 09.2011, p. 307-311.

Research output: Contribution to journalArticle

Agha, Adnan ; Abdulhadi, Mamdouh ; Marenco, Simona ; Bella, Abdelhaleem ; Alsaudi, Dib ; El-Haddad, Ahmed ; Inferrera, Simona ; Savarino, Vincenzo ; Giannini, Edoardo. / Use of the platelet count/spleen diameter ratio for the noninvasive diagnosis of esophageal varices in patients with schistosomiasis. In: Saudi Journal of Gastroenterology. 2011 ; Vol. 17, No. 5. pp. 307-311.
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abstract = "Background/Aim: In patients with liver cirrhosis, the platelet count/spleen diameter ratio has been validated as a parameter for the noninvasive diagnosis of esophageal varices. Schistosoma infection is a frequent cause of portal hypertension in Middle Eastern countries, and is associated with the development of esophageal varices. In this study we aimed to evaluate the platelet count/spleen diameter ratio as a noninvasive tool for the prediction of the presence of esophageal varices in patients with schistosoma-related chronic liver disease. Patients and Methods: Forty-three patients with hepatosplenic schistosomiasis underwent upper digestive endoscopy to check for the presence of esophageal varices. Furthermore, all patients underwent abdominal ultrasonography, and maximum spleen diameter (in mm) was measured. The platelet count/spleen diameter ratio was calculated in all patients. Results: Esophageal varices were found in 31 patients (72{\%}). Age and gender were not significantly different between patients with and without varices. In patients with varices, median platelet count (82,000/L versus 172,000/L, P <0.0001) and platelet count/spleen diameter ratio (571 versus 1651, P <0.0001) were significantly lower, while spleen diameter (147 mm versus 109 mm, P = 0.0006) was significantly larger. In multivariate analysis, the platelet count/spleen diameter ratio was the only parameter independently associated with the presence of varices (P <0.0001). Conclusions: In this study we have validated the use of the platelet count/spleen diameter ratio for the noninvasive diagnosis of esophageal varices in patients with portal hypertension caused by schistosoma infection. In these patients, the platelet count/spleen diameter ratio might be used to allow better rationalization of medical resources and use of endoscopy.",
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AU - Agha, Adnan

AU - Abdulhadi, Mamdouh

AU - Marenco, Simona

AU - Bella, Abdelhaleem

AU - Alsaudi, Dib

AU - El-Haddad, Ahmed

AU - Inferrera, Simona

AU - Savarino, Vincenzo

AU - Giannini, Edoardo

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N2 - Background/Aim: In patients with liver cirrhosis, the platelet count/spleen diameter ratio has been validated as a parameter for the noninvasive diagnosis of esophageal varices. Schistosoma infection is a frequent cause of portal hypertension in Middle Eastern countries, and is associated with the development of esophageal varices. In this study we aimed to evaluate the platelet count/spleen diameter ratio as a noninvasive tool for the prediction of the presence of esophageal varices in patients with schistosoma-related chronic liver disease. Patients and Methods: Forty-three patients with hepatosplenic schistosomiasis underwent upper digestive endoscopy to check for the presence of esophageal varices. Furthermore, all patients underwent abdominal ultrasonography, and maximum spleen diameter (in mm) was measured. The platelet count/spleen diameter ratio was calculated in all patients. Results: Esophageal varices were found in 31 patients (72%). Age and gender were not significantly different between patients with and without varices. In patients with varices, median platelet count (82,000/L versus 172,000/L, P <0.0001) and platelet count/spleen diameter ratio (571 versus 1651, P <0.0001) were significantly lower, while spleen diameter (147 mm versus 109 mm, P = 0.0006) was significantly larger. In multivariate analysis, the platelet count/spleen diameter ratio was the only parameter independently associated with the presence of varices (P <0.0001). Conclusions: In this study we have validated the use of the platelet count/spleen diameter ratio for the noninvasive diagnosis of esophageal varices in patients with portal hypertension caused by schistosoma infection. In these patients, the platelet count/spleen diameter ratio might be used to allow better rationalization of medical resources and use of endoscopy.

AB - Background/Aim: In patients with liver cirrhosis, the platelet count/spleen diameter ratio has been validated as a parameter for the noninvasive diagnosis of esophageal varices. Schistosoma infection is a frequent cause of portal hypertension in Middle Eastern countries, and is associated with the development of esophageal varices. In this study we aimed to evaluate the platelet count/spleen diameter ratio as a noninvasive tool for the prediction of the presence of esophageal varices in patients with schistosoma-related chronic liver disease. Patients and Methods: Forty-three patients with hepatosplenic schistosomiasis underwent upper digestive endoscopy to check for the presence of esophageal varices. Furthermore, all patients underwent abdominal ultrasonography, and maximum spleen diameter (in mm) was measured. The platelet count/spleen diameter ratio was calculated in all patients. Results: Esophageal varices were found in 31 patients (72%). Age and gender were not significantly different between patients with and without varices. In patients with varices, median platelet count (82,000/L versus 172,000/L, P <0.0001) and platelet count/spleen diameter ratio (571 versus 1651, P <0.0001) were significantly lower, while spleen diameter (147 mm versus 109 mm, P = 0.0006) was significantly larger. In multivariate analysis, the platelet count/spleen diameter ratio was the only parameter independently associated with the presence of varices (P <0.0001). Conclusions: In this study we have validated the use of the platelet count/spleen diameter ratio for the noninvasive diagnosis of esophageal varices in patients with portal hypertension caused by schistosoma infection. In these patients, the platelet count/spleen diameter ratio might be used to allow better rationalization of medical resources and use of endoscopy.

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KW - portal hypertension

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