Use of the somatostatin analogue octreotide localise and manage somatostatin-producing tumours

S. Angeletti, V. D. Corleto, O. Schillaci, M. Marignani, B. Annibale, A. Moretti, G. Silecchia, F. Scopinaro, N. Basso, C. Bordi, G. Delle Fave

Research output: Contribution to journalArticlepeer-review

Abstract

Background - Somatostatin receptor scintigraphy (SRS) and octreotide therapy have both changed the management of gastroenteropancreatic endocrine tumours, but very few data are available on the use of SRS and octreotide to visualise and treat somatostatinomas. Method - The results of SRS and octreotide treatment in three somatostatinoma patients were examined. Results - SRS was able to detect extensive hepatic involvement in patient 1, one hepatic and one pancreatic lesion in patient 2, and one hepatic lesion in patient 3. Octreotide therapy (0.5 mg/day subcutaneously) was effective in decreasing plasma levels of somatostatin in all three patients. Symptoms (diabetes and diarrhoea) were greatly improved in the two patients with 'somatostatinoma syndrome'. Conclusion - The study shows that somatostatinoma, like most other gastroenteropancreatic endocrine tumours, possesses functioning somatostatin receptors.

Original languageEnglish
Pages (from-to)792-794
Number of pages3
JournalGut
Volume42
Issue number6
Publication statusPublished - 1998

Keywords

  • Gastroenteropancreatic endocrine tumour
  • Octreotide
  • Somatostatin
  • Somatostatin receptor scintigraphy
  • Somatostatinoma

ASJC Scopus subject areas

  • Gastroenterology

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