Useful applications of growth factors for cardiovascular regenerative medicine

Maria Rosaria De Pascale, Nunzia Della Mura, Michele Vacca, Claudio Napoli

Research output: Contribution to journalReview articlepeer-review


Novel advances for cardiovascular diseases (CVDs) include regenerative approaches for fibrosis, hypertrophy, and neoangiogenesis. Studies indicate that growth factor (GF) signaling could promote heart repair since most of the evidence is derived from preclinical models. Observational studies have evaluated GF serum/plasma levels as feasible biomarkers for risk stratification of CVDs. Noteworthy, two clinical interventional published studies showed that the administration of growth factors (GFs) induced beneficial effect on left ventricular ejection fraction (LVEF), myocardial perfusion, end-systolic volume index (ESVI). To date, large scale ongoing studies are in Phase I-II and mostly focussed on intramyocardial (IM), intracoronary (IC) or intravenous (IV) administration of vascular endothelial growth factor (VEGF) and fibroblast growth factor-23 (FGF-23) which result in the most investigated GFs in the last 10 years. Future data of ongoing randomized controlled studies will be crucial in understanding whether GF-based protocols could be in a concrete way effective in the clinical setting.

Original languageEnglish
Pages (from-to)35-63
Number of pages29
JournalGrowth Factors
Issue number1
Publication statusPublished - Jan 2020


  • cardiovascular diseases
  • fibroblast growth factor
  • Growth factors
  • heart failure
  • vascular endothelial growth factors

ASJC Scopus subject areas

  • Endocrinology
  • Clinical Biochemistry
  • Cell Biology


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