Usefulness and potential pitfalls of sialic acid determination in sera of patients with ovarian tumors.

B. Berra, S. Rapelli, G. Monticelli, M. A. Fighetti, I. Della Mea, F. Raspagliesi, E. Di Re, R. Ringhini, E. Bombardieri

Research output: Contribution to journalArticle

Abstract

Increasing evidence in the literature indicates that serum sialic acid is increased in cancer patients suggesting a possible usefulness of its determination as a tumor marker. However there are many discrepancies in the data reported, probably due to methodological errors, mainly in lipid bound sialic measurement. In this paper we illustrate the results obtained when we applied a method worked out in our laboratory for the determination of total and fractionated sialic acid (lipid and protein bound) to the analysis of sera from patients with ovarian tumors and the preliminary data on the follow up of selected cases. The potential pitfalls in using this relatively new tumor marker will be critically evaluated.

Original languageEnglish
Pages (from-to)39-46
Number of pages8
JournalInternational Journal of Biological Markers
Volume1
Issue number1
Publication statusPublished - Jan 1986

ASJC Scopus subject areas

  • Biochemistry
  • Immunology

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    Berra, B., Rapelli, S., Monticelli, G., Fighetti, M. A., Della Mea, I., Raspagliesi, F., Di Re, E., Ringhini, R., & Bombardieri, E. (1986). Usefulness and potential pitfalls of sialic acid determination in sera of patients with ovarian tumors. International Journal of Biological Markers, 1(1), 39-46.