Abstract
Surgical risk scores fail to accurately predict mortality after transcatheter aortic valve implantation (TAVI). The aimof this study was to develop and validate a dedicated risk score for accurate estimation of mortality risk in these patients. All consecutive patients who underwent TAVI at 6 international institutionswere enrolled. Predictors for 1-year all-causemortality were identified by means of Cox multivariate analysis and incorporated in a prediction score. Accuracy of the score was derived and externally validated for 30-day and 1-year mortality. The net classification improvement comparedwith the Society ofThoracic Surgeons (STS) scorewas appraised. A total of 1,064 patients constituted the derivation cohort and 180 patients constituted the external validation cohort. A total of 165 patients (15%) died at 1-year follow-up. Previous stroke (odds ratio [OR] 1.80, 1.4 to 3), inverse of renal clearance (OR 8, 6 to 14), and systolic pulmonary arterial pressure ≥50mmHg (OR 2.10, 1.5 to 3) were independently related to 1-year mortality. Area under the curve (AUC) of the survival post TAVI (STT) for 1-year mortality was 0.68 (0.62 to 0.71). At 30 days, 65 patients (7%) had died and the AUC for the STT at this time point was 0.66 (0.64 to 0.75). In the external validation cohorts, theAUC of the STT were 0.66 (0.56 to 0.7) for 30-day and 0.67 (0.62 to 0.71) for 1-year mortality. Net reclassification improvement for STT compared with STS was 31% (p
| Original language | English |
|---|---|
| Pages (from-to) | 1867-1874 |
| Number of pages | 8 |
| Journal | The American Journal of Cardiology |
| Volume | 114 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2014 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Medicine(all)
Cite this
Usefulness and validation of the survival post TAVI score for survival after transcatheter aortic valve implantation for aortic stenosis. / D'Ascenzo, Fabrizio; Capodanno, Davide; Tarantini, Giuseppe; Nijhoff, Freek; Ciuca, Cristina; Rossi, Marco Luciano; Brambilla, Nedy; Barbanti, Marco; Napodano, Massimo; Stella, Pieter; Saia, Francesco; Ferrante, Giuseppe; Tamburino, Corrado; Gasparetto, Valeria; Agostoni, Pierfrancesco; Marzocchi, Antonio; Presbitero, Patrizia; Bedogni, Francesco; Cerrato, Enrico; Omedè, Pierluigi; Conrotto, Federico; Salizzoni, Stefano; Zoccai, Giuseppe Biondi; Marra, Sebastiano; Rinaldi, Mauro; Gaita, Fiorenzo; D'Amico, Maurizio; Moretti, Claudio.
In: The American Journal of Cardiology, Vol. 114, No. 12, 2014, p. 1867-1874.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Usefulness and validation of the survival post TAVI score for survival after transcatheter aortic valve implantation for aortic stenosis
AU - D'Ascenzo, Fabrizio
AU - Capodanno, Davide
AU - Tarantini, Giuseppe
AU - Nijhoff, Freek
AU - Ciuca, Cristina
AU - Rossi, Marco Luciano
AU - Brambilla, Nedy
AU - Barbanti, Marco
AU - Napodano, Massimo
AU - Stella, Pieter
AU - Saia, Francesco
AU - Ferrante, Giuseppe
AU - Tamburino, Corrado
AU - Gasparetto, Valeria
AU - Agostoni, Pierfrancesco
AU - Marzocchi, Antonio
AU - Presbitero, Patrizia
AU - Bedogni, Francesco
AU - Cerrato, Enrico
AU - Omedè, Pierluigi
AU - Conrotto, Federico
AU - Salizzoni, Stefano
AU - Zoccai, Giuseppe Biondi
AU - Marra, Sebastiano
AU - Rinaldi, Mauro
AU - Gaita, Fiorenzo
AU - D'Amico, Maurizio
AU - Moretti, Claudio
PY - 2014
Y1 - 2014
N2 - Surgical risk scores fail to accurately predict mortality after transcatheter aortic valve implantation (TAVI). The aimof this study was to develop and validate a dedicated risk score for accurate estimation of mortality risk in these patients. All consecutive patients who underwent TAVI at 6 international institutionswere enrolled. Predictors for 1-year all-causemortality were identified by means of Cox multivariate analysis and incorporated in a prediction score. Accuracy of the score was derived and externally validated for 30-day and 1-year mortality. The net classification improvement comparedwith the Society ofThoracic Surgeons (STS) scorewas appraised. A total of 1,064 patients constituted the derivation cohort and 180 patients constituted the external validation cohort. A total of 165 patients (15%) died at 1-year follow-up. Previous stroke (odds ratio [OR] 1.80, 1.4 to 3), inverse of renal clearance (OR 8, 6 to 14), and systolic pulmonary arterial pressure ≥50mmHg (OR 2.10, 1.5 to 3) were independently related to 1-year mortality. Area under the curve (AUC) of the survival post TAVI (STT) for 1-year mortality was 0.68 (0.62 to 0.71). At 30 days, 65 patients (7%) had died and the AUC for the STT at this time point was 0.66 (0.64 to 0.75). In the external validation cohorts, theAUC of the STT were 0.66 (0.56 to 0.7) for 30-day and 0.67 (0.62 to 0.71) for 1-year mortality. Net reclassification improvement for STT compared with STS was 31% (p
AB - Surgical risk scores fail to accurately predict mortality after transcatheter aortic valve implantation (TAVI). The aimof this study was to develop and validate a dedicated risk score for accurate estimation of mortality risk in these patients. All consecutive patients who underwent TAVI at 6 international institutionswere enrolled. Predictors for 1-year all-causemortality were identified by means of Cox multivariate analysis and incorporated in a prediction score. Accuracy of the score was derived and externally validated for 30-day and 1-year mortality. The net classification improvement comparedwith the Society ofThoracic Surgeons (STS) scorewas appraised. A total of 1,064 patients constituted the derivation cohort and 180 patients constituted the external validation cohort. A total of 165 patients (15%) died at 1-year follow-up. Previous stroke (odds ratio [OR] 1.80, 1.4 to 3), inverse of renal clearance (OR 8, 6 to 14), and systolic pulmonary arterial pressure ≥50mmHg (OR 2.10, 1.5 to 3) were independently related to 1-year mortality. Area under the curve (AUC) of the survival post TAVI (STT) for 1-year mortality was 0.68 (0.62 to 0.71). At 30 days, 65 patients (7%) had died and the AUC for the STT at this time point was 0.66 (0.64 to 0.75). In the external validation cohorts, theAUC of the STT were 0.66 (0.56 to 0.7) for 30-day and 0.67 (0.62 to 0.71) for 1-year mortality. Net reclassification improvement for STT compared with STS was 31% (p
UR - http://www.scopus.com/inward/record.url?scp=84922259485&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922259485&partnerID=8YFLogxK
U2 - 10.1016/j.amjcard.2014.09.031
DO - 10.1016/j.amjcard.2014.09.031
M3 - Article
C2 - 25438915
AN - SCOPUS:84922259485
VL - 114
SP - 1867
EP - 1874
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 12
ER -