Usefulness of 18F Florbetaben in Diagnosis of Alzheimer's Disease and Other Types of Dementia

Agostino Chiaravalloti; Roberta Danieli; Annamaria Lacanfora; Barbara Palumbo; Carlo Caltagirone; Orazio Schillaci

Usefulness of 18F Florbetaben in Diagnosis of Alzheimer's Disease and Other Types of Dementia

Agostino Chiaravalloti, Roberta Danieli, Annamaria Lacanfora, Barbara Palumbo, Carlo Caltagirone, Orazio Schillaci

Research output: Contribution to journal › Article › peer-review

Abstract

In the last decade, several radiolabeled compounds have been developed for the imaging in vivo of amyloid pathology by means of Positron Emission Tomography (PET). Among these, 18F Florbetaben appear to be one of the most reliable for its high affinity for amyloid plaques in brain and its radio-chemical properties that make it usable in common clinical routine. The aim of this review is to provide a general overview of the application in vivo of 18F Florbetaben, describing for first the physiopathological basis of amyloid pathology. Afterwards, the chemical characteristics of this radiolabeled compound will be described, with a particular attention to the synthesis process and the kinetic in vivo. An overview on the imaging protocols and image interpretation will be provided as well and, as a last aspect, the results of the main studies performed in subjects with advanced and early AD will be summarized.

Original language	English
Pages (from-to)	154-160
Number of pages	7
Journal	Current Alzheimer Research
Volume	14
Issue number	2
Publication status	Published - Jun 20 2016

Keywords

Journal Article

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title = "Usefulness of 18F Florbetaben in Diagnosis of Alzheimer's Disease and Other Types of Dementia",

abstract = "In the last decade, several radiolabeled compounds have been developed for the imaging in vivo of amyloid pathology by means of Positron Emission Tomography (PET). Among these, 18F Florbetaben appear to be one of the most reliable for its high affinity for amyloid plaques in brain and its radio-chemical properties that make it usable in common clinical routine. The aim of this review is to provide a general overview of the application in vivo of 18F Florbetaben, describing for first the physiopathological basis of amyloid pathology. Afterwards, the chemical characteristics of this radiolabeled compound will be described, with a particular attention to the synthesis process and the kinetic in vivo. An overview on the imaging protocols and image interpretation will be provided as well and, as a last aspect, the results of the main studies performed in subjects with advanced and early AD will be summarized.",

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author = "Agostino Chiaravalloti and Roberta Danieli and Annamaria Lacanfora and Barbara Palumbo and Carlo Caltagirone and Orazio Schillaci",

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T1 - Usefulness of 18F Florbetaben in Diagnosis of Alzheimer's Disease and Other Types of Dementia

AU - Chiaravalloti, Agostino

AU - Danieli, Roberta

AU - Lacanfora, Annamaria

AU - Palumbo, Barbara

AU - Caltagirone, Carlo

AU - Schillaci, Orazio

PY - 2016/6/20

Y1 - 2016/6/20

N2 - In the last decade, several radiolabeled compounds have been developed for the imaging in vivo of amyloid pathology by means of Positron Emission Tomography (PET). Among these, 18F Florbetaben appear to be one of the most reliable for its high affinity for amyloid plaques in brain and its radio-chemical properties that make it usable in common clinical routine. The aim of this review is to provide a general overview of the application in vivo of 18F Florbetaben, describing for first the physiopathological basis of amyloid pathology. Afterwards, the chemical characteristics of this radiolabeled compound will be described, with a particular attention to the synthesis process and the kinetic in vivo. An overview on the imaging protocols and image interpretation will be provided as well and, as a last aspect, the results of the main studies performed in subjects with advanced and early AD will be summarized.

AB - In the last decade, several radiolabeled compounds have been developed for the imaging in vivo of amyloid pathology by means of Positron Emission Tomography (PET). Among these, 18F Florbetaben appear to be one of the most reliable for its high affinity for amyloid plaques in brain and its radio-chemical properties that make it usable in common clinical routine. The aim of this review is to provide a general overview of the application in vivo of 18F Florbetaben, describing for first the physiopathological basis of amyloid pathology. Afterwards, the chemical characteristics of this radiolabeled compound will be described, with a particular attention to the synthesis process and the kinetic in vivo. An overview on the imaging protocols and image interpretation will be provided as well and, as a last aspect, the results of the main studies performed in subjects with advanced and early AD will be summarized.

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EP - 160

JO - Current Alzheimer Research

JF - Current Alzheimer Research

SN - 1567-2050

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