Usefulness of a serological panel test in the assessment of gastritis in symptomatic children

Gian Luigi De Angelis, Lucas Giovanni Cavallaro, Valentina Maffini, Ali Mahamat Moussa, Fabiola Fornaroli, Stefania Liatopoulou, Barbara Bizzarri, Roberta Merli, Giuseppe Comparato, Pietro Caruana, Giulia Martina Cavestro, Angelo Franzé, Francesco Di Mario

Research output: Contribution to journalArticlepeer-review


Background: Non-invasive methods are advisable for the detection of Helicobacter pylori-related chronic gastritis in pediatric patients. Serum pepsinogens I and II (sPGII and sPGII), gastrin-17 (G-17) and anti-H. pylori antibodies (IgG-Hp) have been proposed as a 'serological gastric biopsy'. Aim: To assess H. pylori infection and to evaluate gastric mucosa status in a pediatric population by means of serological parameters such as sPGI, sPGII, G-17 and IgG-Hp. Methods: 45 consecutively children evaluated for upper gastrointestinal symptoms were analyzed. All children were submitted to upper gastrointestinal endoscopy with biopsies. Serum samples were analyzed for IgG-Hp, sPGII, sPGI and G-17 (Biohit, Helsinki, Finland). Results: 18 children had H. pylori-related mild or moderate non-atrophic chronic gastritis. They presented significantly higher mean levels of sPGII and of IgG-Hp than negative ones, eitherunder or up to 10 years. sPGI showed significantly increased levels in H. pylori-positive patients only over 10 years. G-17 levels were not different between H. pylori-positive and -negative ones. The best cut-offs of IgG-Hp, sPGII and of product IgG-Hp·sPGII, to identify H. pylori infection, were 30 IU/l, 9 μg/l, and 241 IU/l·μg/l, respectively. The product IgG-Hp·sPGII identified H. pylori infection with a 100% sensitivity, 92% specificity, 90% positive predictive value and 100% negative predictive value. IgG-Hp and IgG-Hp showed a correlation (r = 0.94; p <0.001). Conclusions: Combined analysis of sPGII and IgG-Hp antibody levels could be recommended as a non-invasive panel for the assessment of H. pylori-related histological alterations of gastric mucosa in childhood.

Original languageEnglish
Pages (from-to)206-213
Number of pages8
JournalDigestive Diseases
Issue number3
Publication statusPublished - Sep 2007


  • Gastrin-17
  • Gastritis
  • Helicobacter pylori
  • IgG anti-H. pylori antibodies
  • Serum pepsinogens I and II

ASJC Scopus subject areas

  • Gastroenterology
  • Medicine(all)


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