TY - JOUR
T1 - Usefulness of an early neurofunctional assessment in predicting neurodevelopmental outcome in very low birthweight infants
AU - Picciolini, O.
AU - Gianni, M. L.
AU - Vegni, C.
AU - Fumagalli, M.
AU - Mosca, F.
PY - 2006/3
Y1 - 2006/3
N2 - Objective: To evaluate whether early neurofunctional assessment may be useful in predicting neurodevelopmental outcome in children of very low birth weight (VLBW). Design: Observational longitudinal study. Settings: Northern Italy. Patients: A total of 250 VLBW children (129 boys, 121 girls) born consecutively 1996-1999. Main outcome measures: Neurodevelopment at 36 months of chronological age, classified in accordance with the classification of Tardieu and the International classification of functioning. Results: Of the infants exhibiting normal neurodevelopment (n = 183) or major dysfunction (n = 17) at 3 months of corrected age, 72% and 94% respectively did not change their score during the study. Minor dysfunctions at 3 months of corrected age were transient in 17 (34%) children. After adjustment for neonatal variables, neurodevelopment at 3 months of corrected age remained predictive of dysfunction at 36 months (odds ratio = 4.33, 95% confidence interval 2.05 to 9.12). If the results for the normal and minor dysfunction groups were pooled, the predictive qualities of the 3 month neurofunctional assessment were: sensitivity 0.5, specificity 0.99, positive predictive value 0.94, negative predictive value 0.93. Conclusion: Early neurofunctional evaluation may be useful in predicting later neurodevelopmental outcome in VLBW children.
AB - Objective: To evaluate whether early neurofunctional assessment may be useful in predicting neurodevelopmental outcome in children of very low birth weight (VLBW). Design: Observational longitudinal study. Settings: Northern Italy. Patients: A total of 250 VLBW children (129 boys, 121 girls) born consecutively 1996-1999. Main outcome measures: Neurodevelopment at 36 months of chronological age, classified in accordance with the classification of Tardieu and the International classification of functioning. Results: Of the infants exhibiting normal neurodevelopment (n = 183) or major dysfunction (n = 17) at 3 months of corrected age, 72% and 94% respectively did not change their score during the study. Minor dysfunctions at 3 months of corrected age were transient in 17 (34%) children. After adjustment for neonatal variables, neurodevelopment at 3 months of corrected age remained predictive of dysfunction at 36 months (odds ratio = 4.33, 95% confidence interval 2.05 to 9.12). If the results for the normal and minor dysfunction groups were pooled, the predictive qualities of the 3 month neurofunctional assessment were: sensitivity 0.5, specificity 0.99, positive predictive value 0.94, negative predictive value 0.93. Conclusion: Early neurofunctional evaluation may be useful in predicting later neurodevelopmental outcome in VLBW children.
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U2 - 10.1136/adc.2005.073262
DO - 10.1136/adc.2005.073262
M3 - Article
C2 - 16492947
AN - SCOPUS:33644640471
VL - 91
JO - Archives of Disease in Childhood: Fetal and Neonatal Edition
JF - Archives of Disease in Childhood: Fetal and Neonatal Edition
SN - 1359-2998
IS - 2
ER -