Usefulness of an Integrated Analysis of Different Memory Tasks to Predict the Progression from Mild Cognitive Impairment to Alzheimer's Disease: The Episodic Memory Score (EMS)

Camillo Marra, Guido Gainotti, Lucia Fadda, Roberta Perri, Giordano Lacidogna, Eugenia Scaricamazza, Chiara Piccininni, Davide Quaranta

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Taking into account both the severity and the consistency of performances obtained on memory tests by patients with amnestic mild cognitive impairment (aMCI) could improve the power to predict their progression to Alzheimer's disease. For this purpose, we constructed the Episodic Memory Score (EMS), which is obtained by subdividing in tertiles performances obtained at baseline in verbal (RAVLT) and visual episodic memory (Rey-Osterrieth Figure-delayed recall) and giving a score ranging from 1 (worst result) to 3 (best result) to results falling within each tertile. The EMS was computed for each patient by summing the tertile score obtained on each memory task, so that the total score ranged from 4 (worst performance) to 12 (best performance). The aMCI sample consisted of 198 subjects who completed the two-year follow-up, at the end of which 55 subjects had converted to dementia. The mean EMS score obtained by aMCI converters was significantly lower than that of aMCI-stable patients. In detecting conversion to dementia, the comparison between EMS and individual memory scores obtained at baseline was made by computing ROC curves, and estimating the respective area under the curve (AUC). The EMS had a larger AUC than the individual memory scores. At baseline aMCI converters performed worse than non-converters not only on memory tasks, but also on executive functions tasks. However, in a multiple variables logistic regression analysis in which all scores showing statistically significant differences between aMCI-converters and aMCI-stable were entered, the EMS was the only reliable predictor of progression from aMCI to dementia.

Original languageEnglish
Pages (from-to)61-70
Number of pages10
JournalJournal of Alzheimer's Disease
Volume50
Issue number1
DOIs
Publication statusPublished - Nov 30 2015

Fingerprint

Episodic Memory
Alzheimer Disease
Dementia
Area Under Curve
Cognitive Dysfunction
Executive Function
ROC Curve
Logistic Models
Regression Analysis

Keywords

  • Alzheimer's disease
  • amnestic mild cognitive impairment
  • conversion
  • integration of memory scores
  • neuropsychological markers
  • Rey-Osterrieth Complex Figure delayed reproduction
  • verbal immediate and delayed recall

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this

Usefulness of an Integrated Analysis of Different Memory Tasks to Predict the Progression from Mild Cognitive Impairment to Alzheimer's Disease : The Episodic Memory Score (EMS). / Marra, Camillo; Gainotti, Guido; Fadda, Lucia; Perri, Roberta; Lacidogna, Giordano; Scaricamazza, Eugenia; Piccininni, Chiara; Quaranta, Davide.

In: Journal of Alzheimer's Disease, Vol. 50, No. 1, 30.11.2015, p. 61-70.

Research output: Contribution to journalArticle

Marra, Camillo ; Gainotti, Guido ; Fadda, Lucia ; Perri, Roberta ; Lacidogna, Giordano ; Scaricamazza, Eugenia ; Piccininni, Chiara ; Quaranta, Davide. / Usefulness of an Integrated Analysis of Different Memory Tasks to Predict the Progression from Mild Cognitive Impairment to Alzheimer's Disease : The Episodic Memory Score (EMS). In: Journal of Alzheimer's Disease. 2015 ; Vol. 50, No. 1. pp. 61-70.
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