Usefulness of Aspirin Resistance After Percutaneous Coronary Intervention for Acute Myocardial Infarction in Predicting One-Year Major Adverse Coronary Events

Rossella Marcucci, Rita Paniccia, Emilia Antonucci, Anna Maria Gori, Sandra Fedi, Cristina Giglioli, Serafina Valente, Domenico Prisco, Rosanna Abbate, Gian Franco Gensini

Research output: Contribution to journalArticlepeer-review

Abstract

Recently, great interest has focused on the phenomenon of aspirin resistance, which may be defined as clinical or laboratory resistance. Monitoring the antiplatelet effect appears to be relevant in the presence of clinical implications, but no data are available on the possible clinical implications of the failure of aspirin to inhibit tests of platelet function in the setting of acute coronary syndromes. This study evaluated the role of aspirin resistance in the occurrence of 1-year major adverse coronary events (MACEs) in patients with acute myocardial infarction (AMI) who have undergone percutaneous coronary intervention (PCI). We prospectively evaluated 146 patients (115 men and 31 women; median age 65 years, range 30 to 84) with AMI who underwent primary PCI. Exclusion criteria were the use of glycoprotein IIb/IIIa inhibitors, hematocrit ≤30%, and a platelet count 3. Platelet function analyzer-100 closure times by collagen-epinephrine were used for measuring platelet function in venous blood samples obtained 12 to 15 hours after revascularization. Patients were considered aspirin resistant in the presence of a collagen-epinephrine closure time of

Original languageEnglish
Pages (from-to)1156-1159
Number of pages4
JournalThe American Journal of Cardiology
Volume98
Issue number9
DOIs
Publication statusPublished - Nov 1 2006

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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