Usefulness of baseline statin therapy in nonobstructive coronary artery disease by coronary computed tomographic angiography: From the CONFIRM (COronary CT Angiography EvaluatioN for Clinical Outcomes: An InteRnational Multicenter) study

Y.-K. Cho, C.-W. Nam, B.-K. Koo, J. Schulman-Marcus, B.Ó. Hartaigh, H. Gransar, Y. Lu, S. Achenbach, M. Al-Mallah, D. Andreini, J.J. Bax, M.J. Budoff, F. Cademartiri, T.Q. Callister, H.-J. Chang, K. Chinnaiyan, B.J.W. Chow, R.C. Cury, A. Delago, G. FeuchtnerM. Hadamitzky, J. Hausleiter, P.A. Kaufmann, Y.-J. Kim, J. Leipsic, E. Maffei, H. Marques, G. Pontone, G.L. Raff, R. Rubinshtein, L.J. Shaw, T.C. Villines, D.S. Berman, E.C. Jones, J.M. Peña, F.Y. Lin, J.K. Min

Research output: Contribution to journalArticle

Abstract

Background The extent to which the presence and extent of subclinical atherosclerosis by coronary computed tomography angiography influences a potential mortality benefit of statin is unknown. We evaluated the relationship between statin therapy, mortality, and subclinical atherosclerosis. Methods In the CONFIRM study, patients with normal or non-obstructive plaque (
Original languageEnglish
JournalPLoS One
Volume13
Issue number12
DOIs
Publication statusPublished - 2018

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Angiography
atherosclerosis
Coronary Angiography
Multicenter Studies
Coronary Artery Disease
therapeutics
Mortality
computed tomography
Tomography
Atherosclerosis
Therapeutics
Computed Tomography Angiography
coronary artery disease
methodology

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Usefulness of baseline statin therapy in nonobstructive coronary artery disease by coronary computed tomographic angiography: From the CONFIRM (COronary CT Angiography EvaluatioN for Clinical Outcomes: An InteRnational Multicenter) study. / Cho, Y.-K.; Nam, C.-W.; Koo, B.-K.; Schulman-Marcus, J.; Hartaigh, B.Ó.; Gransar, H.; Lu, Y.; Achenbach, S.; Al-Mallah, M.; Andreini, D.; Bax, J.J.; Budoff, M.J.; Cademartiri, F.; Callister, T.Q.; Chang, H.-J.; Chinnaiyan, K.; Chow, B.J.W.; Cury, R.C.; Delago, A.; Feuchtner, G.; Hadamitzky, M.; Hausleiter, J.; Kaufmann, P.A.; Kim, Y.-J.; Leipsic, J.; Maffei, E.; Marques, H.; Pontone, G.; Raff, G.L.; Rubinshtein, R.; Shaw, L.J.; Villines, T.C.; Berman, D.S.; Jones, E.C.; Peña, J.M.; Lin, F.Y.; Min, J.K.

In: PLoS One, Vol. 13, No. 12, 2018.

Research output: Contribution to journalArticle

Cho, Y-K, Nam, C-W, Koo, B-K, Schulman-Marcus, J, Hartaigh, BÓ, Gransar, H, Lu, Y, Achenbach, S, Al-Mallah, M, Andreini, D, Bax, JJ, Budoff, MJ, Cademartiri, F, Callister, TQ, Chang, H-J, Chinnaiyan, K, Chow, BJW, Cury, RC, Delago, A, Feuchtner, G, Hadamitzky, M, Hausleiter, J, Kaufmann, PA, Kim, Y-J, Leipsic, J, Maffei, E, Marques, H, Pontone, G, Raff, GL, Rubinshtein, R, Shaw, LJ, Villines, TC, Berman, DS, Jones, EC, Peña, JM, Lin, FY & Min, JK 2018, 'Usefulness of baseline statin therapy in nonobstructive coronary artery disease by coronary computed tomographic angiography: From the CONFIRM (COronary CT Angiography EvaluatioN for Clinical Outcomes: An InteRnational Multicenter) study', PLoS One, vol. 13, no. 12. https://doi.org/10.1371/journal.pone.0207194
Cho, Y.-K. ; Nam, C.-W. ; Koo, B.-K. ; Schulman-Marcus, J. ; Hartaigh, B.Ó. ; Gransar, H. ; Lu, Y. ; Achenbach, S. ; Al-Mallah, M. ; Andreini, D. ; Bax, J.J. ; Budoff, M.J. ; Cademartiri, F. ; Callister, T.Q. ; Chang, H.-J. ; Chinnaiyan, K. ; Chow, B.J.W. ; Cury, R.C. ; Delago, A. ; Feuchtner, G. ; Hadamitzky, M. ; Hausleiter, J. ; Kaufmann, P.A. ; Kim, Y.-J. ; Leipsic, J. ; Maffei, E. ; Marques, H. ; Pontone, G. ; Raff, G.L. ; Rubinshtein, R. ; Shaw, L.J. ; Villines, T.C. ; Berman, D.S. ; Jones, E.C. ; Peña, J.M. ; Lin, F.Y. ; Min, J.K. / Usefulness of baseline statin therapy in nonobstructive coronary artery disease by coronary computed tomographic angiography: From the CONFIRM (COronary CT Angiography EvaluatioN for Clinical Outcomes: An InteRnational Multicenter) study. In: PLoS One. 2018 ; Vol. 13, No. 12.
@article{049bfc96d4ee4149b54caef3c9db3721,
title = "Usefulness of baseline statin therapy in nonobstructive coronary artery disease by coronary computed tomographic angiography: From the CONFIRM (COronary CT Angiography EvaluatioN for Clinical Outcomes: An InteRnational Multicenter) study",
abstract = "Background The extent to which the presence and extent of subclinical atherosclerosis by coronary computed tomography angiography influences a potential mortality benefit of statin is unknown. We evaluated the relationship between statin therapy, mortality, and subclinical atherosclerosis. Methods In the CONFIRM study, patients with normal or non-obstructive plaque (",
author = "Y.-K. Cho and C.-W. Nam and B.-K. Koo and J. Schulman-Marcus and B.{\'O}. Hartaigh and H. Gransar and Y. Lu and S. Achenbach and M. Al-Mallah and D. Andreini and J.J. Bax and M.J. Budoff and F. Cademartiri and T.Q. Callister and H.-J. Chang and K. Chinnaiyan and B.J.W. Chow and R.C. Cury and A. Delago and G. Feuchtner and M. Hadamitzky and J. Hausleiter and P.A. Kaufmann and Y.-J. Kim and J. Leipsic and E. Maffei and H. Marques and G. Pontone and G.L. Raff and R. Rubinshtein and L.J. Shaw and T.C. Villines and D.S. Berman and E.C. Jones and J.M. Pe{\~n}a and F.Y. Lin and J.K. Min",
note = "Export Date: 1 February 2019 CODEN: POLNC Correspondence Address: Nam, C.-W.; Department of Cardiology, Keimyung University Dongsan Medical CenterSouth Korea; email: ncwcv@dsmc.or.kr References: Stone, N.J., Robinson, J., Lichtenstein, A.H., Merz, C.N., Blum, C.B., Eckel, R.H., 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: A report of the American college of cardiology/American Heart Association task force on practice guidelines (2013) Circulation, , PMID: 24222016; De Azevedo, C.F., Hadlich, M.S., Bezerra, S.G., Petriz, J.L., Alves, R.R., De Souza, O., Prognostic value of CT angiography in patients with inconclusive functional stress tests (2011) JACC Cardiovascular Imaging., 4 (7), pp. 740-751. , PMID: 21757164; Habib, P.J., Green, J., Butterfield, R.C., Kuntz, G.M., Murthy, R., Kraemer, D.F., Association of cardiac events with coronary artery disease detected by 64-slice or greater coronary CT angiography: A systematic review and meta-analysis (2013) International Journal of Cardiology., 169 (2), pp. 112-120. , PMID: 24090745; De Graaf, M.A., Broersen, A., Ahmed, W., Kitslaar, P.H., Dijkstra, J., Kroft, L.J., Feasibility of an automated quantitative computed tomography angiography-derived risk score for risk stratification of patients with suspected coronary artery disease (2014) Am J Cardiol., 113 (12), pp. 1947-1955. , PMID: 24798123; Bittencourt, M.S., Hulten, E., Ghoshhajra, B., O'Leary, D., Christman, M.P., Montana, P., Prognostic value of nonobstructive and obstructive coronary artery disease detected by coronary computed tomography angiography to identify cardiovascular events (2014) Circulation Cardiovascular Imaging., 7 (2), pp. 282-291. , PMID: 24550435; Min, J.K., Labounty, T.M., Gomez, M.J., Achenbach, S., Al-Mallah, M., Budoff, M.J., Incremental prognostic value of coronary computed tomographic angiography over coronary artery calcium score for risk prediction of major adverse cardiac events in asymptomatic diabetic individuals (2014) Atherosclerosis., 232 (2), pp. 298-304. , PMID: 24468142; Ahmed, K., Jeong, M.H., Chakraborty, R., Hong, Y.J., Sim, D.S., Hwang, S.H., Percutaneous coronary intervention with drug-eluting stent implantation vs. coronary artery bypass grafting for multivessel coronary artery disease in metabolic syndrome patients with acute myocardial infarction (2012) Circ J., 76 (3), pp. 721-728. , PMID: 22240598; Min, J.K., Dunning, A., Lin, F.Y., Achenbach, S., Al-Mallah, M.H., Berman, D.S., Rationale and design of the CONFIRM (COronary CT Angiography EvaluatioN for Clinical Outcomes: An InteRnational Multicenter) Registry (2011) Journal of Cardiovascular Computed Tomography., 5 (2), pp. 84-92. , PMID: 21477786; Raff, G.L., Abidov, A., Achenbach, S., Berman, D.S., Boxt, L.M., Budoff, M.J., SCCT guidelines for the interpretation and reporting of coronary computed tomographic angiography (2009) Journal of Cardiovascular Computed Tomography., 3 (2), pp. 122-136. , PMID: 19272853; Agatston, A.S., Janowitz, W.R., Hildner, F.J., Zusmer, N.R., Viamonte, M., Jr., Detrano, R., Quantification of coronary artery calcium using ultrafast computed tomography (1990) Journal of the American College of Cardiology., 15 (4), pp. 827-832. , PMID: 2407762; Greenland, P., LaBree, L., Azen, S.P., Doherty, T.M., Detrano, R.C., Coronary artery calcium score combined with Framingham score for risk prediction in asymptomatic individuals (2004) JAMA: The Journal of the American Medical Association., 291 (2), pp. 210-215. , PMID: 14722147; Min, J.K., Shaw, L.J., Devereux, R.B., Okin, P.M., Weinsaft, J.W., Russo, D.J., Prognostic value of multidetector coronary computed tomographic angiography for prediction of all-cause mortality (2007) J Am Coll Cardiol., 50 (12), pp. 1161-1170. , PMID: 17868808; Abdulla, J., Asferg, C., Kofoed, K.F., Prognostic value of absence or presence of coronary artery disease determined by 64-slice computed tomography coronary angiography a systematic review and metaanalysis (2011) The International Journal of Cardiovascular Imaging., 27 (3), pp. 413-420. , PMID: 20549366; Nakazato, R., Arsanjani, R., Achenbach, S., Gransar, H., Cheng, V.Y., Dunning, A., Age-related risk of major adverse cardiac event risk and coronary artery disease extent and severity by coronary CT angiography: Results from 15 187 patients from the International Multisite CONFIRM Study (2014) European Heart Journal Cardiovascular Imaging., 15 (5), pp. 586-594. , PMID: 24714312; Stone, G.W., Maehara, A., Lansky, A.J., De Bruyne, B., Cristea, E., Mintz, G.S., A prospective natural-history study of coronary atherosclerosis (2011) N Engl J Med., 364 (3), pp. 226-235. , Epub 2011/01/21. PMID: 21247313; Schulman-Marcus, J., Gransar, H., Lin, F., Valenti, V., Cho, I., Sex-Specific Associations between Coronary Artery Plaque Extent and Risk of Major Adverse Cardiovascular Events: The CONFIRM Long-Term Registry (2016) JACC Cardiovascular Imaging., 9 (4), pp. 364-372. , PMID: 27056154; Maddox, T.M., Stanislawski, M.A., Grunwald, G.K., Bradley, S.M., Ho, P.M., Tsai, T.T., Nonobstructive coronary artery disease and risk of myocardial infarction (2014) JAMA: The Journal of the American Medical Association., 312 (17), pp. 1754-1763. , PMID: 25369489; Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S) (1994) Lancet, 344 (8934), pp. 1383-1389. , PMID: 7968073; Gutierrez, J., Ramirez, G., Rundek, T., Sacco, R.L., Statin therapy in the prevention of recurrent cardiovascular events: A sex-based meta-analysis (2012) Archives of Internal Medicine., 172 (12), pp. 909-919. , PMID: 22732744; Mills, E.J., Rachlis, B., Wu, P., Devereaux, P.J., Arora, P., Perri, D., Primary prevention of cardiovascular mortality and events with statin treatments: A network meta-analysis involving more than 65, 000 patients (2008) Journal of the American College of Cardiology., 52 (22), pp. 1769-1781. , PMID: 19022156; Taylor, F.C., Huffman, M., Ebrahim, S., Statin therapy for primary prevention of cardiovascular disease (2013) JAMA: The Journal of the American Medical Association., 310 (22), pp. 2451-2452. , PMID: 24276813; Zeb, I., Li, D., Nasir, K., Malpeso, J., Batool, A., Flores, F., Effect of statin treatment on coronary plaque progression-A serial coronary CT angiography study (2013) Atherosclerosis., 231 (2), pp. 198-204. , PMID: 24267226; Otagiri, K., Tsutsui, H., Kumazaki, S., Miyashita, Y., Aizawa, K., Koshikawa, M., Early intervention with rosuvastatin decreases the lipid components of the plaque in acute coronary syndrome: Analysis using integrated backscatter IVUS (ELAN study) (2011) Circulation Journal: Official Journal of the Japanese Circulation Society., 75 (3), pp. 633-641. , PMID: 21266787; Hoffmann, H., Frieler, K., Schlattmann, P., Hamm, B., Dewey, M., Influence of statin treatment on coronary atherosclerosis visualised using multidetector computed tomography (2010) European Radiology., 20 (12), pp. 2824-2833. , PMID: 20640900; De Bruyne, B., Pijls, N.H., Kalesan, B., Barbato, E., Tonino, P.A., Piroth, Z., Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease (2012) N Engl J Med., 367 (11), pp. 991-1001. , Epub 2012/08/29. PMID: 22924638; Chow, B.J., Small, G., Yam, Y., Chen, L., McPherson, R., Achenbach, S., Prognostic and therapeutic implications of statin and aspirin therapy in individuals with nonobstructive coronary artery disease: Results from the CONFIRM (COronary CT Angiography EvaluatioN for Clinical Outcomes: An InteRnational Multicenter registry) registry (2015) Arterioscler Thromb Vasc Biol., 35 (4), pp. 981-989. , Epub 2015/02/14. PMID: 25676000; Cholesterol Treatment Trialists, C., Fulcher, J., O'Connell, R., Voysey, M., Emberson, J., Blackwell, L., Efficacy and safety of LDL-lowering therapy among men and women: Meta-analysis of individual data from 174, 000 participants in 27 randomised trials (2015) Lancet., 385 (9976), pp. 1397-1405. , Epub 2015/01/ 13. PMID: 25579834; Nakazato, R., Gransar, H., Berman, D.S., Cheng, V.Y., Lin, F.Y., Achenbach, S., Statins use and coronary artery plaque composition: Results from the International Multicenter CONFIRM Registry (2012) Atherosclerosis., 225 (1), pp. 148-153. , Epub 2012/09/18. PMID: 22981406",
year = "2018",
doi = "10.1371/journal.pone.0207194",
language = "English",
volume = "13",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "12",

}

TY - JOUR

T1 - Usefulness of baseline statin therapy in nonobstructive coronary artery disease by coronary computed tomographic angiography: From the CONFIRM (COronary CT Angiography EvaluatioN for Clinical Outcomes: An InteRnational Multicenter) study

AU - Cho, Y.-K.

AU - Nam, C.-W.

AU - Koo, B.-K.

AU - Schulman-Marcus, J.

AU - Hartaigh, B.Ó.

AU - Gransar, H.

AU - Lu, Y.

AU - Achenbach, S.

AU - Al-Mallah, M.

AU - Andreini, D.

AU - Bax, J.J.

AU - Budoff, M.J.

AU - Cademartiri, F.

AU - Callister, T.Q.

AU - Chang, H.-J.

AU - Chinnaiyan, K.

AU - Chow, B.J.W.

AU - Cury, R.C.

AU - Delago, A.

AU - Feuchtner, G.

AU - Hadamitzky, M.

AU - Hausleiter, J.

AU - Kaufmann, P.A.

AU - Kim, Y.-J.

AU - Leipsic, J.

AU - Maffei, E.

AU - Marques, H.

AU - Pontone, G.

AU - Raff, G.L.

AU - Rubinshtein, R.

AU - Shaw, L.J.

AU - Villines, T.C.

AU - Berman, D.S.

AU - Jones, E.C.

AU - Peña, J.M.

AU - Lin, F.Y.

AU - Min, J.K.

N1 - Export Date: 1 February 2019 CODEN: POLNC Correspondence Address: Nam, C.-W.; Department of Cardiology, Keimyung University Dongsan Medical CenterSouth Korea; email: ncwcv@dsmc.or.kr References: Stone, N.J., Robinson, J., Lichtenstein, A.H., Merz, C.N., Blum, C.B., Eckel, R.H., 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: A report of the American college of cardiology/American Heart Association task force on practice guidelines (2013) Circulation, , PMID: 24222016; De Azevedo, C.F., Hadlich, M.S., Bezerra, S.G., Petriz, J.L., Alves, R.R., De Souza, O., Prognostic value of CT angiography in patients with inconclusive functional stress tests (2011) JACC Cardiovascular Imaging., 4 (7), pp. 740-751. , PMID: 21757164; Habib, P.J., Green, J., Butterfield, R.C., Kuntz, G.M., Murthy, R., Kraemer, D.F., Association of cardiac events with coronary artery disease detected by 64-slice or greater coronary CT angiography: A systematic review and meta-analysis (2013) International Journal of Cardiology., 169 (2), pp. 112-120. , PMID: 24090745; De Graaf, M.A., Broersen, A., Ahmed, W., Kitslaar, P.H., Dijkstra, J., Kroft, L.J., Feasibility of an automated quantitative computed tomography angiography-derived risk score for risk stratification of patients with suspected coronary artery disease (2014) Am J Cardiol., 113 (12), pp. 1947-1955. , PMID: 24798123; Bittencourt, M.S., Hulten, E., Ghoshhajra, B., O'Leary, D., Christman, M.P., Montana, P., Prognostic value of nonobstructive and obstructive coronary artery disease detected by coronary computed tomography angiography to identify cardiovascular events (2014) Circulation Cardiovascular Imaging., 7 (2), pp. 282-291. , PMID: 24550435; Min, J.K., Labounty, T.M., Gomez, M.J., Achenbach, S., Al-Mallah, M., Budoff, M.J., Incremental prognostic value of coronary computed tomographic angiography over coronary artery calcium score for risk prediction of major adverse cardiac events in asymptomatic diabetic individuals (2014) Atherosclerosis., 232 (2), pp. 298-304. , PMID: 24468142; Ahmed, K., Jeong, M.H., Chakraborty, R., Hong, Y.J., Sim, D.S., Hwang, S.H., Percutaneous coronary intervention with drug-eluting stent implantation vs. coronary artery bypass grafting for multivessel coronary artery disease in metabolic syndrome patients with acute myocardial infarction (2012) Circ J., 76 (3), pp. 721-728. , PMID: 22240598; Min, J.K., Dunning, A., Lin, F.Y., Achenbach, S., Al-Mallah, M.H., Berman, D.S., Rationale and design of the CONFIRM (COronary CT Angiography EvaluatioN for Clinical Outcomes: An InteRnational Multicenter) Registry (2011) Journal of Cardiovascular Computed Tomography., 5 (2), pp. 84-92. , PMID: 21477786; Raff, G.L., Abidov, A., Achenbach, S., Berman, D.S., Boxt, L.M., Budoff, M.J., SCCT guidelines for the interpretation and reporting of coronary computed tomographic angiography (2009) Journal of Cardiovascular Computed Tomography., 3 (2), pp. 122-136. , PMID: 19272853; Agatston, A.S., Janowitz, W.R., Hildner, F.J., Zusmer, N.R., Viamonte, M., Jr., Detrano, R., Quantification of coronary artery calcium using ultrafast computed tomography (1990) Journal of the American College of Cardiology., 15 (4), pp. 827-832. , PMID: 2407762; Greenland, P., LaBree, L., Azen, S.P., Doherty, T.M., Detrano, R.C., Coronary artery calcium score combined with Framingham score for risk prediction in asymptomatic individuals (2004) JAMA: The Journal of the American Medical Association., 291 (2), pp. 210-215. , PMID: 14722147; Min, J.K., Shaw, L.J., Devereux, R.B., Okin, P.M., Weinsaft, J.W., Russo, D.J., Prognostic value of multidetector coronary computed tomographic angiography for prediction of all-cause mortality (2007) J Am Coll Cardiol., 50 (12), pp. 1161-1170. , PMID: 17868808; Abdulla, J., Asferg, C., Kofoed, K.F., Prognostic value of absence or presence of coronary artery disease determined by 64-slice computed tomography coronary angiography a systematic review and metaanalysis (2011) The International Journal of Cardiovascular Imaging., 27 (3), pp. 413-420. , PMID: 20549366; Nakazato, R., Arsanjani, R., Achenbach, S., Gransar, H., Cheng, V.Y., Dunning, A., Age-related risk of major adverse cardiac event risk and coronary artery disease extent and severity by coronary CT angiography: Results from 15 187 patients from the International Multisite CONFIRM Study (2014) European Heart Journal Cardiovascular Imaging., 15 (5), pp. 586-594. , PMID: 24714312; Stone, G.W., Maehara, A., Lansky, A.J., De Bruyne, B., Cristea, E., Mintz, G.S., A prospective natural-history study of coronary atherosclerosis (2011) N Engl J Med., 364 (3), pp. 226-235. , Epub 2011/01/21. PMID: 21247313; Schulman-Marcus, J., Gransar, H., Lin, F., Valenti, V., Cho, I., Sex-Specific Associations between Coronary Artery Plaque Extent and Risk of Major Adverse Cardiovascular Events: The CONFIRM Long-Term Registry (2016) JACC Cardiovascular Imaging., 9 (4), pp. 364-372. , PMID: 27056154; Maddox, T.M., Stanislawski, M.A., Grunwald, G.K., Bradley, S.M., Ho, P.M., Tsai, T.T., Nonobstructive coronary artery disease and risk of myocardial infarction (2014) JAMA: The Journal of the American Medical Association., 312 (17), pp. 1754-1763. , PMID: 25369489; Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S) (1994) Lancet, 344 (8934), pp. 1383-1389. , PMID: 7968073; Gutierrez, J., Ramirez, G., Rundek, T., Sacco, R.L., Statin therapy in the prevention of recurrent cardiovascular events: A sex-based meta-analysis (2012) Archives of Internal Medicine., 172 (12), pp. 909-919. , PMID: 22732744; Mills, E.J., Rachlis, B., Wu, P., Devereaux, P.J., Arora, P., Perri, D., Primary prevention of cardiovascular mortality and events with statin treatments: A network meta-analysis involving more than 65, 000 patients (2008) Journal of the American College of Cardiology., 52 (22), pp. 1769-1781. , PMID: 19022156; Taylor, F.C., Huffman, M., Ebrahim, S., Statin therapy for primary prevention of cardiovascular disease (2013) JAMA: The Journal of the American Medical Association., 310 (22), pp. 2451-2452. , PMID: 24276813; Zeb, I., Li, D., Nasir, K., Malpeso, J., Batool, A., Flores, F., Effect of statin treatment on coronary plaque progression-A serial coronary CT angiography study (2013) Atherosclerosis., 231 (2), pp. 198-204. , PMID: 24267226; Otagiri, K., Tsutsui, H., Kumazaki, S., Miyashita, Y., Aizawa, K., Koshikawa, M., Early intervention with rosuvastatin decreases the lipid components of the plaque in acute coronary syndrome: Analysis using integrated backscatter IVUS (ELAN study) (2011) Circulation Journal: Official Journal of the Japanese Circulation Society., 75 (3), pp. 633-641. , PMID: 21266787; Hoffmann, H., Frieler, K., Schlattmann, P., Hamm, B., Dewey, M., Influence of statin treatment on coronary atherosclerosis visualised using multidetector computed tomography (2010) European Radiology., 20 (12), pp. 2824-2833. , PMID: 20640900; De Bruyne, B., Pijls, N.H., Kalesan, B., Barbato, E., Tonino, P.A., Piroth, Z., Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease (2012) N Engl J Med., 367 (11), pp. 991-1001. , Epub 2012/08/29. PMID: 22924638; Chow, B.J., Small, G., Yam, Y., Chen, L., McPherson, R., Achenbach, S., Prognostic and therapeutic implications of statin and aspirin therapy in individuals with nonobstructive coronary artery disease: Results from the CONFIRM (COronary CT Angiography EvaluatioN for Clinical Outcomes: An InteRnational Multicenter registry) registry (2015) Arterioscler Thromb Vasc Biol., 35 (4), pp. 981-989. , Epub 2015/02/14. PMID: 25676000; Cholesterol Treatment Trialists, C., Fulcher, J., O'Connell, R., Voysey, M., Emberson, J., Blackwell, L., Efficacy and safety of LDL-lowering therapy among men and women: Meta-analysis of individual data from 174, 000 participants in 27 randomised trials (2015) Lancet., 385 (9976), pp. 1397-1405. , Epub 2015/01/ 13. PMID: 25579834; Nakazato, R., Gransar, H., Berman, D.S., Cheng, V.Y., Lin, F.Y., Achenbach, S., Statins use and coronary artery plaque composition: Results from the International Multicenter CONFIRM Registry (2012) Atherosclerosis., 225 (1), pp. 148-153. , Epub 2012/09/18. PMID: 22981406

PY - 2018

Y1 - 2018

N2 - Background The extent to which the presence and extent of subclinical atherosclerosis by coronary computed tomography angiography influences a potential mortality benefit of statin is unknown. We evaluated the relationship between statin therapy, mortality, and subclinical atherosclerosis. Methods In the CONFIRM study, patients with normal or non-obstructive plaque (

AB - Background The extent to which the presence and extent of subclinical atherosclerosis by coronary computed tomography angiography influences a potential mortality benefit of statin is unknown. We evaluated the relationship between statin therapy, mortality, and subclinical atherosclerosis. Methods In the CONFIRM study, patients with normal or non-obstructive plaque (

U2 - 10.1371/journal.pone.0207194

DO - 10.1371/journal.pone.0207194

M3 - Article

VL - 13

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 12

ER -