Usefulness of calcaneal quantitative ultrasound stiffness for the evaluation of bone health in HIV-1-infected subjects: Comparison with dual X-ray absorptiometry

Alessandra Fantauzzi, Marco Floridia, Fabrizio Ceci, Francesco Cacciatore, Vincenzo Vullo, Ivano Mezzaroma

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: With the development of effective treatments and the resulting increase in life expectancy, bone mineral density (BMD) alteration has emerged as an important comorbidity in human immunodeficiency virus type-1 (HIV-1)-infected individuals. The potential contributors to the pathogenesis of osteopenia/osteoporosis include a higher prevalence of risk factors, combined antiretroviral therapy (cART)-exposure, HIV-1 itself and chronic immune activation/inflammation. Dual-energy X-ray absorptiometry (DXA) is the “gold standard” technique for assessing bone status in HIV-1 population. Methods: We conducted a cross-sectional study to investigate bone mineral status in a group of 158 HIV-1-infected subjects. The primary endpoint was the feasibility of calcaneal quantitative ultrasound (QUS) as a screening tool for BMD. All subjects were receiving stable cART and were virologically suppressed (HIV-RNA

Original languageEnglish
Pages (from-to)109-117
Number of pages9
JournalHIV/AIDS - Research and Palliative Care
Volume8
DOIs
Publication statusPublished - May 31 2016

Keywords

  • Bone mineral density
  • Calcaneal quantitative ultrasound
  • DXA
  • Fracture risk

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology
  • Health Policy
  • Epidemiology
  • Dermatology

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