Usefulness of computerized electroencephalography in diagnosing, staging and monitoring AIDS-dementia complex

Aldo Parisi, Giovanni di Petri, Maurizio Strosselli, Giuseppe Nappi, Lorenzo Minoli, Elio Guido Rondanelli

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One hundred and one subjects, with various degrees of HIV infection, were enrolled in a longitudinal study aimed at evaluating the correlation between clinical and instrumental findings in the development of HIV-related subacute encephalitis. The method used was electroencephalography coupled with computerized spectral analysis (EEG-CSA) and mapping. The findings recorded by this method were compared with those obtained by computed tomography (CT) scan and neurological examination. The EEG-CSA findings were divided into four categories according to their severity. EEG-CSA was shown to be very sensitive in detecting the first signs of a forthcoming neurological disease. Following 11 months of observation, 22 out of 40 (55%) neurologically asymptomatic individuals who, at the beginning of the study showed some EEG-CSA abnormalities, had clinical evidence of a subacute encephalitis whereas only two out of 37 (5.4%) subjects who were previously free of EEG-CSA abnormalities had some signs of neurological disease (P <0.001) after the same period. Of those remaining who were already symptomatic when the study started, the neurological progression of HIV infection was also monitored by EEG-CSA.

Original languageEnglish
Pages (from-to)209-213
Number of pages5
JournalAIDS (London, England)
Issue number4
Publication statusPublished - 1989


  • AIDS
  • AIDS-dementia complex
  • Computerized electroencephalography (EEG-CSA)

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Infectious Diseases


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