Usefulness of Coronary Sinus Reducer Implantation for the Treatment of Chronic Refractory Angina Pectoris

Gianpiero D'Amico, Francesco Giannini, Mauro Massussi, Matteo Tebaldi, Alessandro Cafaro, Alfonso Ielasi, Fabio Sgura, Federico De Marco, Giulio G Stefanini, Marco Ciardetti, Francesco Versaci, Roberto A Latini, Salvatore Saccà, Sergio Ghiringhelli, Andrea Picchi, Marco Cerrito, Achille Gaspardone, Giuseppe Tarantini

Research output: Contribution to journalArticlepeer-review

Abstract

The coronary sinus (CS) Reducer is a novel device designed for the management of patients with severe angina symptoms refractory to optimal medical therapy and not amenable to further revascularization. Aim of this study was to investigate the efficacy and the safety of the CS Reducer device in a real-world, multicenter, and country-level cohort of patients presenting with refractory angina pectoris. The study included patients affected by refractory angina pectoris who underwent CS Reducer implantation in 16 centers. Clinical follow-up was carried as per each center's protocol. One hundred eighty-seven patients were included. Technical and procedural success were achieved in 98% and 95%, respectively. Minor peri-procedural complications were recorded in 8 patients. During a median follow-up of 18.4 months, 135 (82.8%) patients demonstrated at least 1 CCS class reduction after Reducer implantation, and 80 (49%) patients at least 2 CCS class reduction. Mean CCS class improved from 3.05 ± 0.53 at baseline to 1.63 ± 0.98 at follow-up (p < 0.001). Treatment benefit was also reflected in a significant improvement in quality of life scores and in a reduction of the mean number of anti-ischemic drugs prescribed for patient. In conclusion, in this multicenter, country-level study, the implantation of CS Reducer in patients with refractory angina pectoris resulted to be safe and effective in reducing of angina pectoris and improving quality of life.

Original languageEnglish
Pages (from-to)22-27
Number of pages6
JournalThe American Journal of Cardiology
Volume139
DOIs
Publication statusPublished - Jan 15 2021

Keywords

  • Aged
  • Angina Pectoris/diagnosis
  • Chronic Disease
  • Coronary Angiography
  • Coronary Sinus
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Prosthesis Implantation/methods
  • Retrospective Studies
  • Stents
  • Time Factors
  • Treatment Outcome

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