Usefulness of exercise test in the diagnosis of short QT syndrome

Carla Giustetto, Chiara Scrocco, Rainer Schimpf, Philippe Maury, Andrea Mazzanti, Marco Levetto, Olli Anttonen, Paola Dalmasso, Natascia Cerrato, Elena Gribaudo, Christian Wolpert, Daniela Giachino, Charles Antzelevitch, Martin Borggrefe, Fiorenzo Gaita

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Aims Short QT syndrome (SQTS) is a rare arrhythmogenic inherited heart disease. Diagnosis can be challenging in subjects with slightly shortened QT interval at electrocardiogram. In this study we compared the QT interval behaviour during exercise in a cohort of SQTS patients with a control group, to evaluate the usefulness of exercise test in the diagnosis of SQTS. Methods and results Twenty-one SQTS patients and 20 matched control subjects underwent an exercise test. QT interval was measured at different heart rates (HRs), at rest and during effort. The relation between QT interval and HR was evaluated by linear regression analysis according to the formula: QT = β ×HR + α, where β is the slope of the linear relation, and α is the intercept. Rest and peak exercise HRs were not different in the two groups. Short QT syndrome patients showed lower QT intervals as compared with controls both at rest (276 ± 27 ms vs. 364 ± 25 ms, P <0.0001) and at peak exercise (228 ± 27 ms vs. 245 ± 26 ms, P = 0.05), with a mean variation from rest to peak effort of 48 ± 14 ms vs. 120 ± 20 ms (P <0.0001). Regression analysis of QT/HR relationship revealed a less steep slope for SQTS patients compared with the control group, never exceeding the value of -0.90 ms/beat/min (mean value -0.53 ± 0.15 ms/beat/min vs. -1.29 ± 0.30 ms/beat/min, P <0.0001). Conclusion Short QT syndrome patients show a reduced adaptation of the QT interval to HR. Exercise test can be a useful tool in the diagnosis of SQTS.

Original languageEnglish
Pages (from-to)628-634
Number of pages7
JournalEuropace
Volume17
Issue number4
DOIs
Publication statusPublished - Apr 1 2015

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Exercise Test
Heart Rate
Exercise
Regression Analysis
Control Groups
SHORT syndrome
Linear Models
Heart Diseases
Electrocardiography

Keywords

  • Exercise test
  • Genetics
  • Short QT syndrome

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)
  • Medicine(all)

Cite this

Giustetto, C., Scrocco, C., Schimpf, R., Maury, P., Mazzanti, A., Levetto, M., ... Gaita, F. (2015). Usefulness of exercise test in the diagnosis of short QT syndrome. Europace, 17(4), 628-634. https://doi.org/10.1093/europace/euu351

Usefulness of exercise test in the diagnosis of short QT syndrome. / Giustetto, Carla; Scrocco, Chiara; Schimpf, Rainer; Maury, Philippe; Mazzanti, Andrea; Levetto, Marco; Anttonen, Olli; Dalmasso, Paola; Cerrato, Natascia; Gribaudo, Elena; Wolpert, Christian; Giachino, Daniela; Antzelevitch, Charles; Borggrefe, Martin; Gaita, Fiorenzo.

In: Europace, Vol. 17, No. 4, 01.04.2015, p. 628-634.

Research output: Contribution to journalArticle

Giustetto, C, Scrocco, C, Schimpf, R, Maury, P, Mazzanti, A, Levetto, M, Anttonen, O, Dalmasso, P, Cerrato, N, Gribaudo, E, Wolpert, C, Giachino, D, Antzelevitch, C, Borggrefe, M & Gaita, F 2015, 'Usefulness of exercise test in the diagnosis of short QT syndrome', Europace, vol. 17, no. 4, pp. 628-634. https://doi.org/10.1093/europace/euu351
Giustetto C, Scrocco C, Schimpf R, Maury P, Mazzanti A, Levetto M et al. Usefulness of exercise test in the diagnosis of short QT syndrome. Europace. 2015 Apr 1;17(4):628-634. https://doi.org/10.1093/europace/euu351
Giustetto, Carla ; Scrocco, Chiara ; Schimpf, Rainer ; Maury, Philippe ; Mazzanti, Andrea ; Levetto, Marco ; Anttonen, Olli ; Dalmasso, Paola ; Cerrato, Natascia ; Gribaudo, Elena ; Wolpert, Christian ; Giachino, Daniela ; Antzelevitch, Charles ; Borggrefe, Martin ; Gaita, Fiorenzo. / Usefulness of exercise test in the diagnosis of short QT syndrome. In: Europace. 2015 ; Vol. 17, No. 4. pp. 628-634.
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abstract = "Aims Short QT syndrome (SQTS) is a rare arrhythmogenic inherited heart disease. Diagnosis can be challenging in subjects with slightly shortened QT interval at electrocardiogram. In this study we compared the QT interval behaviour during exercise in a cohort of SQTS patients with a control group, to evaluate the usefulness of exercise test in the diagnosis of SQTS. Methods and results Twenty-one SQTS patients and 20 matched control subjects underwent an exercise test. QT interval was measured at different heart rates (HRs), at rest and during effort. The relation between QT interval and HR was evaluated by linear regression analysis according to the formula: QT = β ×HR + α, where β is the slope of the linear relation, and α is the intercept. Rest and peak exercise HRs were not different in the two groups. Short QT syndrome patients showed lower QT intervals as compared with controls both at rest (276 ± 27 ms vs. 364 ± 25 ms, P <0.0001) and at peak exercise (228 ± 27 ms vs. 245 ± 26 ms, P = 0.05), with a mean variation from rest to peak effort of 48 ± 14 ms vs. 120 ± 20 ms (P <0.0001). Regression analysis of QT/HR relationship revealed a less steep slope for SQTS patients compared with the control group, never exceeding the value of -0.90 ms/beat/min (mean value -0.53 ± 0.15 ms/beat/min vs. -1.29 ± 0.30 ms/beat/min, P <0.0001). Conclusion Short QT syndrome patients show a reduced adaptation of the QT interval to HR. Exercise test can be a useful tool in the diagnosis of SQTS.",
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AU - Maury, Philippe

AU - Mazzanti, Andrea

AU - Levetto, Marco

AU - Anttonen, Olli

AU - Dalmasso, Paola

AU - Cerrato, Natascia

AU - Gribaudo, Elena

AU - Wolpert, Christian

AU - Giachino, Daniela

AU - Antzelevitch, Charles

AU - Borggrefe, Martin

AU - Gaita, Fiorenzo

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N2 - Aims Short QT syndrome (SQTS) is a rare arrhythmogenic inherited heart disease. Diagnosis can be challenging in subjects with slightly shortened QT interval at electrocardiogram. In this study we compared the QT interval behaviour during exercise in a cohort of SQTS patients with a control group, to evaluate the usefulness of exercise test in the diagnosis of SQTS. Methods and results Twenty-one SQTS patients and 20 matched control subjects underwent an exercise test. QT interval was measured at different heart rates (HRs), at rest and during effort. The relation between QT interval and HR was evaluated by linear regression analysis according to the formula: QT = β ×HR + α, where β is the slope of the linear relation, and α is the intercept. Rest and peak exercise HRs were not different in the two groups. Short QT syndrome patients showed lower QT intervals as compared with controls both at rest (276 ± 27 ms vs. 364 ± 25 ms, P <0.0001) and at peak exercise (228 ± 27 ms vs. 245 ± 26 ms, P = 0.05), with a mean variation from rest to peak effort of 48 ± 14 ms vs. 120 ± 20 ms (P <0.0001). Regression analysis of QT/HR relationship revealed a less steep slope for SQTS patients compared with the control group, never exceeding the value of -0.90 ms/beat/min (mean value -0.53 ± 0.15 ms/beat/min vs. -1.29 ± 0.30 ms/beat/min, P <0.0001). Conclusion Short QT syndrome patients show a reduced adaptation of the QT interval to HR. Exercise test can be a useful tool in the diagnosis of SQTS.

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