Usefulness of IFN-gamma release assays in clinical management of difficult TB cases: Evidence from clinical practice

Marialuisa Bocchino, A. Matarese, B. Bellofiore, P. Giacomelli, A. Russo, G. Signoriello, D. Galati, A. Sanduzzi

Research output: Contribution to journalArticlepeer-review

Abstract

Performance of T-SPOT.TB™ (TS-TB) and QuantiFERON TB Gold-In tube (QFT-IT) assays was evaluated for detection of M. tuberculosis (Mtb) infection in patients with suspected extra-pulmonary or smear-negative pulmonary tuberculosis (TB) in a low prevalence country. Twenty-one out of 35 patients were affected by active TB. Mtb culture isolation was achieved in 76% of cases. Tuberculin skin testing (TST), TS-TB, and QFT-IT yielded a positive result in 67%, 95% and 81% of cases, respectively. Agreement of interferon-γ release assays and TST was 70% (κ=0.18 for TS-TB; κ=0.46 for QFT-IT). Increased sensitivity of blood assays (>80%) improved diagnostic evaluation of difficult TB cases.

Original languageEnglish
Pages (from-to)43-47
Number of pages5
JournalEuropean Journal of Inflammation
Volume8
Issue number1
Publication statusPublished - Jan 2010

Keywords

  • Extra-pulmonary tuberculosis
  • IFN-gamma release assays
  • Smear-negative tuberculosis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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