Abstract
Idiopathic erythrocytosis (IE) is a primary erythrocytosis not fulfilling the criteria for polycythemia vera (PV) diagnosis. In order to verify the relationship between IE and PV, we screened JAK2V617F mutation in a consecutive series of 11 IE and, for comparison, in 15 PV. JAK2V617F mutation was screened by both cDNA sequencing and mutation specific PCR in both peripheral blood and bone marrow samples. All 11 IE tested negative for JAK2V617F mutation, which, conversely, occurred in 11/15 (73.3%) PV. Our results demonstrate that JAK2V617F is absent in IE and may represent a useful molecular marker for distinguishing IE from PV.
| Original language | English |
|---|---|
| Pages (from-to) | 97-101 |
| Number of pages | 5 |
| Journal | Leukemia Research |
| Volume | 31 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2007 |
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Keywords
- Chronic myeloproliferative disorders
- Idiopathic erythrocytosis
- JAK2
- Polycythemia vera
- Primary erythrocytosis
ASJC Scopus subject areas
- Cancer Research
- Hematology
- Oncology
Cite this
Usefulness of JAK2V617F mutation in distinguishing idiopathic erythrocytosis from polycythemia vera. / Rossi, Davide; Cortini, Francesca; Deambrogi, Clara; Barbieri, Caterina; Cerri, Michaela; Franceschetti, Silvia; Conconi, Annarita; Capello, Daniela; Gaidano, Gianluca.
In: Leukemia Research, Vol. 31, No. 1, 01.2007, p. 97-101.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Usefulness of JAK2V617F mutation in distinguishing idiopathic erythrocytosis from polycythemia vera
AU - Rossi, Davide
AU - Cortini, Francesca
AU - Deambrogi, Clara
AU - Barbieri, Caterina
AU - Cerri, Michaela
AU - Franceschetti, Silvia
AU - Conconi, Annarita
AU - Capello, Daniela
AU - Gaidano, Gianluca
PY - 2007/1
Y1 - 2007/1
N2 - Idiopathic erythrocytosis (IE) is a primary erythrocytosis not fulfilling the criteria for polycythemia vera (PV) diagnosis. In order to verify the relationship between IE and PV, we screened JAK2V617F mutation in a consecutive series of 11 IE and, for comparison, in 15 PV. JAK2V617F mutation was screened by both cDNA sequencing and mutation specific PCR in both peripheral blood and bone marrow samples. All 11 IE tested negative for JAK2V617F mutation, which, conversely, occurred in 11/15 (73.3%) PV. Our results demonstrate that JAK2V617F is absent in IE and may represent a useful molecular marker for distinguishing IE from PV.
AB - Idiopathic erythrocytosis (IE) is a primary erythrocytosis not fulfilling the criteria for polycythemia vera (PV) diagnosis. In order to verify the relationship between IE and PV, we screened JAK2V617F mutation in a consecutive series of 11 IE and, for comparison, in 15 PV. JAK2V617F mutation was screened by both cDNA sequencing and mutation specific PCR in both peripheral blood and bone marrow samples. All 11 IE tested negative for JAK2V617F mutation, which, conversely, occurred in 11/15 (73.3%) PV. Our results demonstrate that JAK2V617F is absent in IE and may represent a useful molecular marker for distinguishing IE from PV.
KW - Chronic myeloproliferative disorders
KW - Idiopathic erythrocytosis
KW - JAK2
KW - Polycythemia vera
KW - Primary erythrocytosis
UR - http://www.scopus.com/inward/record.url?scp=33750743094&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33750743094&partnerID=8YFLogxK
U2 - 10.1016/j.leukres.2006.02.027
DO - 10.1016/j.leukres.2006.02.027
M3 - Article
C2 - 16620973
AN - SCOPUS:33750743094
VL - 31
SP - 97
EP - 101
JO - Leukemia Research
JF - Leukemia Research
SN - 0145-2126
IS - 1
ER -