Usefulness of knemometry in the assessment of oxandrolone effects and role of infections in short-term growth within constitutional growth delay

G. Guzzaloni, G. Grugni, D. Moro, A. Minocci, F. Morabito

Research output: Contribution to journalArticlepeer-review

Abstract

The knemometer is a non invasive device for measuring leg length and evaluating stature variations otherwise not detected with Harpenden stadiometer. In several clinical conditions of short stature, the knemometer allows to evaluate the short-term effect of growth promoting agents, as well as the role of infections in growth dynamics. In view of these reports we have evaluated the short-term (56-105 days) variation of the leg length in 4 subjects with constitutional growth delay (CGD), treated with oxandrolone at the dose of 0.03 mg/kg/day. The measurements were performed weekly by the same operator, on the same weekday and at the same daytime. The results show that oxandrolone is a useful pharmacological approach to CGD: a positive effect was observed some 40 days after the treatment had been started, as well as a subsequent, progressive increase of the leg length, without evident stature variations. Furthermore a correlation between intercurrent diseases and growth failure, as well as growth resumption at the end of the illness were found.

Original languageEnglish
Pages (from-to)21-27
Number of pages7
JournalActa Medica Auxologica
Volume29
Issue number1
Publication statusPublished - 1997

Keywords

  • constitutional growth delay
  • knemometry
  • oxandrolone

ASJC Scopus subject areas

  • Medicine(all)

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