Usefulness of plasma exchange in recurrent nephrotic syndrome following renal transplant

L. Torretta, C. Perotti, L. Costamagna, A. Tarantino, L. Salvaneschi

Research output: Contribution to journalArticle

Abstract

Nephrotic syndrome due to focal segmental glomerulosclerosis (FSGS) frequently recurs even after transplantation and may cause failure of the renal allograft. We report a case in which plasma exchange (PE) was used to treat a 32-year-old patient with biopsy-proven recurrence of FSGS in a second renal transplant after the first allograft had failed. One year after the second renal graft, the patient presented with proteinuria of 5 g/day and a creatinine level of 1.46 mg/dl. A course of 9 PE was performed over a 15-day period. Proteinuria improved rapidly, and 20 days after the last PE, it was already down to 0.8 g/day. This level continued to decrease progressively (0.5 g/day after 3 months) and reached zero after approximately 6 months. Eleven months after PE treatment, the patient had no proteinuria and his plasma creatinine level was normal. In our opinion PE should be instituted early in recurrent nephrotic syndrome after renal transplantation. The optimum frequency of such treatment still has to be established, especially with regard to its use as long-term maintenance therapy.

Original languageEnglish
Pages (from-to)96-98
Number of pages3
JournalArtificial Organs
Volume19
Issue number1
Publication statusPublished - 1995

Keywords

  • Nephrotic syndrome
  • Plasma exchange
  • Recurrent focal segmental glomerulosclerosis
  • Renal transplantation

ASJC Scopus subject areas

  • Biophysics

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