Usefulness of screening for congenital or acquired hemostatic abnormalities in women with previous complicated pregnancies

Giorgio Mello, Elena Parretti, Elisabetta Martini, Federico Mecacci, Pasquale La Torre, Riccardo Cioni, Roberto Lucchetti, Sandra Fedi, Anna Maria Gori, Guglielmina Pepe, Domenico Prisco, Rosanna Abbate

Research output: Contribution to journalArticle

Abstract

Activated protein C resistance (APCR) is a common cause of familial thrombophilia and venous thrombosis. The aim of the study was to investigate the prevalence of APCR associated with factor V Leiden mutation and its relevance in comparison to other risk factors for thromboembolic disorders in women with a history of previous complicated pregnancies (history of fetal loss in the second and third trimester n = 34, preeclampsia n = 46). The frequency of APCR was significantly higher in women with a history of fetal loss and preeclampsia (23.5 and 26.1%, respectively) compared with a control group (3.8%). The prevalence of antithrombin, protein C and protein S deficiencies and the presence of antiphospholipid antibodies were also investigated: the prevalence of at least one disorder was 41.2% in the group with previous fetal loss, 37.0% in the group with previous preeclampsia and 7.5% in the control group. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)197-203
Number of pages7
JournalHaemostasis
Volume29
Issue number4
Publication statusPublished - Mar 2000

Keywords

  • Activated protein C resistance
  • Factor V Leiden
  • Fetal loss
  • Preeclampsia

ASJC Scopus subject areas

  • Hematology

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    Mello, G., Parretti, E., Martini, E., Mecacci, F., La Torre, P., Cioni, R., Lucchetti, R., Fedi, S., Gori, A. M., Pepe, G., Prisco, D., & Abbate, R. (2000). Usefulness of screening for congenital or acquired hemostatic abnormalities in women with previous complicated pregnancies. Haemostasis, 29(4), 197-203.