Abstract
The diagnosis of childhood-onset growth hormone (GH) deficiency (GHD) is not straightforward, requiring a comprehensive clinical, anthropometric, biochemical, endocrine, and neuroradiological assessment. Although pharmacological GH stimulation tests are still considered the gold standard for GHD diagnosis, they are burdened by both poor specificity and side effects. The measurement of insulin-like growth factor I (IGF-I), due to its close GH dependency, was proposed for diagnosing GHD. However, a number of factors may affect the measurements. Herein, we propose an algorithm based on both IGF-I determination and anthropometry, aimed at simplifying the diagnosis of GHD in prepubertal children.
| Original language | English |
|---|---|
| Pages (from-to) | 145-148 |
| Number of pages | 4 |
| Journal | Hormone Research in Paediatrics |
| Volume | 74 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jul 2010 |
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Keywords
- Growth hormone deficiency
- Insulin-like growth factor I
- Short stature
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
- Pediatrics, Perinatology, and Child Health
Cite this
Usefulness of serum insulin-like growth factor i assessment in the diagnosis of childhood-Onset growth hormone deficiency. / Federico, Giovanni; Cianfarani, Stefano.
In: Hormone Research in Paediatrics, Vol. 74, No. 2, 07.2010, p. 145-148.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Usefulness of serum insulin-like growth factor i assessment in the diagnosis of childhood-Onset growth hormone deficiency
AU - Federico, Giovanni
AU - Cianfarani, Stefano
PY - 2010/7
Y1 - 2010/7
N2 - The diagnosis of childhood-onset growth hormone (GH) deficiency (GHD) is not straightforward, requiring a comprehensive clinical, anthropometric, biochemical, endocrine, and neuroradiological assessment. Although pharmacological GH stimulation tests are still considered the gold standard for GHD diagnosis, they are burdened by both poor specificity and side effects. The measurement of insulin-like growth factor I (IGF-I), due to its close GH dependency, was proposed for diagnosing GHD. However, a number of factors may affect the measurements. Herein, we propose an algorithm based on both IGF-I determination and anthropometry, aimed at simplifying the diagnosis of GHD in prepubertal children.
AB - The diagnosis of childhood-onset growth hormone (GH) deficiency (GHD) is not straightforward, requiring a comprehensive clinical, anthropometric, biochemical, endocrine, and neuroradiological assessment. Although pharmacological GH stimulation tests are still considered the gold standard for GHD diagnosis, they are burdened by both poor specificity and side effects. The measurement of insulin-like growth factor I (IGF-I), due to its close GH dependency, was proposed for diagnosing GHD. However, a number of factors may affect the measurements. Herein, we propose an algorithm based on both IGF-I determination and anthropometry, aimed at simplifying the diagnosis of GHD in prepubertal children.
KW - Growth hormone deficiency
KW - Insulin-like growth factor I
KW - Short stature
UR - http://www.scopus.com/inward/record.url?scp=77954792833&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77954792833&partnerID=8YFLogxK
U2 - 10.1159/000314895
DO - 10.1159/000314895
M3 - Article
C2 - 20551620
AN - SCOPUS:77954792833
VL - 74
SP - 145
EP - 148
JO - Hormone Research in Paediatrics
JF - Hormone Research in Paediatrics
SN - 1663-2818
IS - 2
ER -