Usefulness of serum insulin-like growth factor i assessment in the diagnosis of childhood-Onset growth hormone deficiency

Giovanni Federico, Stefano Cianfarani

Research output: Contribution to journalArticle

Abstract

The diagnosis of childhood-onset growth hormone (GH) deficiency (GHD) is not straightforward, requiring a comprehensive clinical, anthropometric, biochemical, endocrine, and neuroradiological assessment. Although pharmacological GH stimulation tests are still considered the gold standard for GHD diagnosis, they are burdened by both poor specificity and side effects. The measurement of insulin-like growth factor I (IGF-I), due to its close GH dependency, was proposed for diagnosing GHD. However, a number of factors may affect the measurements. Herein, we propose an algorithm based on both IGF-I determination and anthropometry, aimed at simplifying the diagnosis of GHD in prepubertal children.

Original languageEnglish
Pages (from-to)145-148
Number of pages4
JournalHormone Research in Paediatrics
Volume74
Issue number2
DOIs
Publication statusPublished - Jul 2010

Keywords

  • Growth hormone deficiency
  • Insulin-like growth factor I
  • Short stature

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pediatrics, Perinatology, and Child Health

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