Usefulness of serum pepsinogens in helicobacter pylori chronic gastritis: Relationship with inflammation, activity, and density of the bacterium

Francesco Di Mario, Lucas Giovanni Cavallaro, Ali Mahamat Moussa, Pietro Caruana, Roberta Merli, Andrea Maini, Simone Bertolini, Nadia Dal Bó, Massimo Rugge, Giulia Martina Cavestro, Giovanni Aragona, Mario Plebani, Angelo Franzé, Giorgio Nervi

Research output: Contribution to journalArticle

Abstract

We sought to study the relationship between serum pepsinogens and different histopathologic features of Helicobacter pylori-related chronic gastritis. One hundred forty-nine consecutive dyspeptic patients underwent endoscopy with biopsies; serum pepsinogens I and II were measured by immunoassay. Serum levels of pepsinogens (sPG) were significantly correlated with H. pylori density both of the corpus (sPGI: r = 0.32, P <.001; sPGII: r = 0.56, P <.001) and antrum (sPGI: r = 0.41, P <.001; sPGII: r = 0.43, P <.001) as well as with chronic inflammation (sPGI: r = 0.26, P <.001; sPGII: r = 0.49, P <.001) and activity (sPGI: r = 0.38, P <.001; sPGII: r = 0.50, P <.001) in the antrum. Only sPGII was correlated with chronic inflammation (r = 0.44, P <.001) and activity (r = 0.40, P <.001) in the corpus. SPGI was inversely correlated with atrophy (r = -0.33, P <.001) and intestinal metaplasia (r = -0.37, P <.001) in the corpus. sPGII levels could be considered as markers of gastric inflammation all over in the stomach. sPGI levels are inversely related to atrophic body gastritis.

Original languageEnglish
Pages (from-to)1791-1795
Number of pages5
JournalDigestive Diseases and Sciences
Volume51
Issue number10
DOIs
Publication statusPublished - Oct 2006

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Keywords

  • Activity
  • Atrophy
  • Chronic inflammation
  • Helicobacter pylori density
  • Serum pepsinogens

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Di Mario, F., Cavallaro, L. G., Moussa, A. M., Caruana, P., Merli, R., Maini, A., Bertolini, S., Dal Bó, N., Rugge, M., Cavestro, G. M., Aragona, G., Plebani, M., Franzé, A., & Nervi, G. (2006). Usefulness of serum pepsinogens in helicobacter pylori chronic gastritis: Relationship with inflammation, activity, and density of the bacterium. Digestive Diseases and Sciences, 51(10), 1791-1795. https://doi.org/10.1007/s10620-006-9206-1