Usefulness of [111In-DTPA0] octreotide scintigraphy in a family with von Hippel-Lindau disease

M. Pulcrano, L. Camera, L. Pagano, S. Del Vecchio, D. Ferone, L. Bodei, A. Murgia, L. Pace, G. Storto, G. Paganelli, A. Colao, M. Salvatore, G. Lombardi, B. Biondi

Research output: Contribution to journalArticle

Abstract

The identification of patients with von Hippel-Lindau (VHL) disease dictates accurate genetic counseling of family members, whereas screening for early detection of visceral and neurological involvement is usually performed by a combination of radiological and nuclear medicine techniques such as ultrasonography or contrast-enhanced computed tomography of the upper abdomen, magnetic resonance imaging of the central nervous system and 131I-metaiodobenzylguanidine-scintigraphy. The role of 111-indium-diethylenetriaminepentaacetic acid [111In-DTPA0] octreotide scintigraphy in this clinical context has never been investigated. Here, we report imaging findings in a VHL patient and in 3 consecutive family members undergoing clinical and radiological screening that included [111In-DTPA0] octreoticle scintigraphy in addition to the above-mentioned procedures. Somatostatin receptor expression was investigated in vitro by immunohistochemistry in pancreatic tumor sections. On the basis of in vivo and in vitro findings, octreotide long-acting release treatment followed by 90Y-1, 4,7,10-Tetraazacyclododecane-N, N',N'',N'''-tetraacetic acid (DOTA0)-Tyr3-octreotide led to a lack of progression in this patient although this result is a possibility which needs to be proved by further investigation and longer follow-up. The results of this study suggest that [111In-DTPA0] octreotide scintigraphy may be helpful in the routine work-up of VHL patients for diagnostic and therapeutic purposes.

Original languageEnglish
Pages (from-to)352-359
Number of pages8
JournalJournal of Endocrinological Investigation
Volume31
Issue number4
Publication statusPublished - Apr 2008

Keywords

  • [In-DTPA]
  • MIBG scintigraphy
  • Neuroendocrine tumors
  • Octreotide scintigraphy
  • Pheochromocytoma
  • Von Hippel-Lindau disease

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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  • Cite this

    Pulcrano, M., Camera, L., Pagano, L., Del Vecchio, S., Ferone, D., Bodei, L., Murgia, A., Pace, L., Storto, G., Paganelli, G., Colao, A., Salvatore, M., Lombardi, G., & Biondi, B. (2008). Usefulness of [111In-DTPA0] octreotide scintigraphy in a family with von Hippel-Lindau disease. Journal of Endocrinological Investigation, 31(4), 352-359.