Usefulness of the addition of heart rate variability to Holter monitoring in predicting in-hospital cardiac events in patients with unstable angina pectoris

Gaetano Antonio Lanza, Patrizia Pedrotti, Antonio Giuseppe Rebuzzi, Vincenzo Pasceri, Gaetano Quaranta, Attilio Maseri

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Abstract

Transient ischemia on Holter monitoring is a major determinant of outcome in unstable angina. In this study we investigated whether analysis of heart rate variability (HRV) may further improve the prognostic yield of Holter monitoring in this clinical setting. We performed 24-hour Holter monitoring in 75 patients with unstable angina (59 men, aged 62 ±9 years) within 12 hours of hospital admission. Number and duration of myocardial ischemic episodes, and bath time domain and frequency domain HRV measures were obtained from Holter recordings. In-hospital major cardiac events (death or myocardial infarction) occurred in 7 patients (9%). Episodes of ST- segment depression on Holter monitoring were found in 6 of 7 patients (86%) with and in 26 of 68 patients (38%) without events (p 50 ms (pNN50), and square root of the mean squared differences of successive RR intervals) (RMSSD), and frequency domain (ultra low, very low, low, and high frequency) HRV indexes. However, the low-frequency/high-frequency (LF/HF) ratio was significantly higher in patients with cardiac events (2.12 ± 1.4 vs 1.48 ±0.5, p = 0.01). Moreover, when considering only the 32 patients with myocardial ischemic episodes on Holter monitoring, the LF/HF ratio was again higher in the 6 patients with than the 26 patients WithOut major cardiac events (2.45 ± 1.5 vs 1.31 ± 0.3, p

Original languageEnglish
Pages (from-to)263-267
Number of pages5
JournalThe American Journal of Cardiology
Volume80
Issue number3
DOIs
Publication statusPublished - Aug 1 1997

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Ambulatory Electrocardiography
Unstable Angina
Heart Rate
Baths
Ischemia
Myocardial Infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Usefulness of the addition of heart rate variability to Holter monitoring in predicting in-hospital cardiac events in patients with unstable angina pectoris. / Lanza, Gaetano Antonio; Pedrotti, Patrizia; Rebuzzi, Antonio Giuseppe; Pasceri, Vincenzo; Quaranta, Gaetano; Maseri, Attilio.

In: The American Journal of Cardiology, Vol. 80, No. 3, 01.08.1997, p. 263-267.

Research output: Contribution to journalArticle

Lanza, Gaetano Antonio ; Pedrotti, Patrizia ; Rebuzzi, Antonio Giuseppe ; Pasceri, Vincenzo ; Quaranta, Gaetano ; Maseri, Attilio. / Usefulness of the addition of heart rate variability to Holter monitoring in predicting in-hospital cardiac events in patients with unstable angina pectoris. In: The American Journal of Cardiology. 1997 ; Vol. 80, No. 3. pp. 263-267.
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