Usefulness of the dipyridamole-Doppler test for diagnosis of coronary artery disease

Luciano Agati, Luciano Arata, Carlo Peraldo Neja, Carla Manzara, Carlo Iacoboni, Carmine D. Vizza, Maria Penco, Francesco Fedele, Armando Dagianti

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Two-dimensional and Doppler echocardiographic studies and a hemodynamic investigation were performed during dipyridamole testing in 42 subjects (13 control subjects and 29 patients with coronary artery disease [CAD]), to evaluate the ability of dipyridamole Doppler echocardiography in identifying patients with ischemic left ventricular dysfunction. In the control group, after dipyridamole infusion, Doppler-derived parameters increased significantly from baseline (p <0.001). In patients with CAD, peak flow velocity, flow velocity integral and stroke volume failed to increase after dipyridamole infusion (0.89 ± 0.21 to 0.85 ± 0.18 m/s, difference not significant; 14 ± 3 to 12 ± 4 cm, difference not significant, and 56 ± 13 to 50 ± 14 ml/ beat, p <0.05, respectively). Heart rate, rate pressure product, systemic vascular resistance and mean right atrial pressure had similar variations in the 2 groups. Changes in the 3 Doppler-derived parameters are closely related to the variations of peak positive dP dt, stroke volume (thermodilution) and left ventricular end-diastolic pressure and are closely related to the coronary angiography jeopardy score and to the appearance of wall motion abnormalities. Thus, by combining Doppler and 2-dimensional echocardiography, dipyridamole-induced myocardial ischemia may be detected in a high percentage of CAD patients, providing a sensitive tool for identifying patients with high-risk coronary artery anatomy.

Original languageEnglish
Pages (from-to)829-834
Number of pages6
JournalThe American Journal of Cardiology
Volume65
Issue number13
DOIs
Publication statusPublished - Apr 1 1990

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Dipyridamole
Coronary Artery Disease
Stroke Volume
Thermodilution
Atrial Pressure
Doppler Echocardiography
Left Ventricular Dysfunction
Coronary Angiography
Vascular Resistance
Myocardial Ischemia
Echocardiography
Anatomy
Coronary Vessels
Heart Rate
Hemodynamics
Blood Pressure
Pressure
Control Groups

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Agati, L., Arata, L., Neja, C. P., Manzara, C., Iacoboni, C., Vizza, C. D., ... Dagianti, A. (1990). Usefulness of the dipyridamole-Doppler test for diagnosis of coronary artery disease. The American Journal of Cardiology, 65(13), 829-834. https://doi.org/10.1016/0002-9149(90)91422-3

Usefulness of the dipyridamole-Doppler test for diagnosis of coronary artery disease. / Agati, Luciano; Arata, Luciano; Neja, Carlo Peraldo; Manzara, Carla; Iacoboni, Carlo; Vizza, Carmine D.; Penco, Maria; Fedele, Francesco; Dagianti, Armando.

In: The American Journal of Cardiology, Vol. 65, No. 13, 01.04.1990, p. 829-834.

Research output: Contribution to journalArticle

Agati, L, Arata, L, Neja, CP, Manzara, C, Iacoboni, C, Vizza, CD, Penco, M, Fedele, F & Dagianti, A 1990, 'Usefulness of the dipyridamole-Doppler test for diagnosis of coronary artery disease', The American Journal of Cardiology, vol. 65, no. 13, pp. 829-834. https://doi.org/10.1016/0002-9149(90)91422-3
Agati, Luciano ; Arata, Luciano ; Neja, Carlo Peraldo ; Manzara, Carla ; Iacoboni, Carlo ; Vizza, Carmine D. ; Penco, Maria ; Fedele, Francesco ; Dagianti, Armando. / Usefulness of the dipyridamole-Doppler test for diagnosis of coronary artery disease. In: The American Journal of Cardiology. 1990 ; Vol. 65, No. 13. pp. 829-834.
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