Utilità del saggio Hevylite nella gestione clinica di una paziente affetta da amiloidosi AL con gammopatia biclonale

Translated title of the contribution: Usefulness of the hevylite assay in the management of a patient with al amyloidosis and biclonal gammopathy

Veronica Valentini, Francesca Lavatelli, Paolo Milani, Francesca Russo, Marco Basset, Tiziana Bosoni, Laura Pirolini, Filomena Li Bergolis, Gabriele Sarais, Giovanni Palladini, Giampaolo Merlini

Research output: Contribution to journalArticlepeer-review

Abstract

Patients with AL amyloidosis often have small monoclonal components (MCs) difficult to quantify by densitometry. IgA are the most problematic, due to anodic migration and possible masking under proteins migrating in β zone. We evaluated the usefulness of the Hevylite assay (Binding Site, Birmingham UK), at diagnosis and during follow-up, in a patient with AL amyloidosis and biclonal gammopathy. At diagnosis serum immunofixation identified an IgGλ and an IgAλ band (the last one not reliably quantifiable in capillary electrophoresis). The k serum free light chain (FLC) concentration was 4,94 mg/L and λ 26 mg/L (κ/λ ratio 0,19). The Hevylite test showed both IgGλ and IgAλ above the reference limits, with abnormal κ/λ ratios. After treatment, a 27% decrease in IgGλ and a 56% decrease in IgAλ concentration were documented by Hevylite, which was the only mean to quantify the monoclonal components in this patient.

Translated title of the contributionUsefulness of the hevylite assay in the management of a patient with al amyloidosis and biclonal gammopathy
Original languageItalian
Pages (from-to)e12-e15
JournalBiochimica Clinica
Volume40
Issue number2
DOIs
Publication statusPublished - 2016

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical
  • Medical Laboratory Technology

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