Using genetic findings in autism for the development of new pharmaceutical compounds

Jacob A S Vorstman, Will Spooren, Antonio M. Persico, David A. Collier, Stefan Aigner, Ravi Jagasia, Jeffrey C. Glennon, Jan K. Buitelaar

Research output: Contribution to journalArticlepeer-review


Rationale: The main reason for the current lack of effective treatments for the core symptoms of autism is our limited understanding of the biological mechanisms underlying this heterogeneous group of disorders. A primary value of genetic research is enhancing our insight into the biology of autism through the study of identified autism risk genes. Objectives: In the current review we discuss (1) the genes and loci that are associated with autism, (2) how these provide us with essential cues as to what neurobiological mechanisms may be involved, and (3) how these mechanisms may be used as targets for novel treatments. Next, we provide an overview of currently ongoing clinical trials registered at with a variety of compounds. Finally, we review current approaches used to translate knowledge derived from gene discovery into novel pharmaceutical compounds and discuss their pitfalls and problems. Conclusions: An increasing number of genetic variants associated with autism have been identified. This will generate new ideas about the biological mechanisms involved in autism, which in turn may provide new leads for the development of novel pharmaceutical compounds. To optimize this pipeline of drug discovery, large-scale international collaborations are needed for gene discovery, functional validation of risk genes, and improvement of clinical outcome measures and clinical trial methodology in autism.

Original languageEnglish
Pages (from-to)1063-1078
Number of pages16
Issue number6
Publication statusPublished - Mar 2014


  • Autism
  • Biomarker
  • Genes
  • Neurobiology
  • Pharmaceutical compounds

ASJC Scopus subject areas

  • Pharmacology


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