TY - JOUR
T1 - Using what is accessible to measure that which is not
T2 - Necessity of model of system
AU - Cobelli, Claudio
AU - Caumo, Andrea
PY - 1998
Y1 - 1998
N2 - Understanding the in vivo functioning of endocrine-metabolic systems requires the quantitative knowledge of system parameters like production/utilization of substrates, secretion/degradation of homones, and substrate-hormone signaling. Unfortunately, these system parameters are not directly accessible and an indirect measurement approach is needed based on a model of the system. We review first the principals of the model of system methodology focusing on compartmental and input-output modeling. Then, the model of system methodology is applied to the measurement of nonaccessible parameters/variables of the glucose system like glucose fluxes, insulin fluxes, and glucose-insulin signaling.
AB - Understanding the in vivo functioning of endocrine-metabolic systems requires the quantitative knowledge of system parameters like production/utilization of substrates, secretion/degradation of homones, and substrate-hormone signaling. Unfortunately, these system parameters are not directly accessible and an indirect measurement approach is needed based on a model of the system. We review first the principals of the model of system methodology focusing on compartmental and input-output modeling. Then, the model of system methodology is applied to the measurement of nonaccessible parameters/variables of the glucose system like glucose fluxes, insulin fluxes, and glucose-insulin signaling.
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U2 - 10.1016/S0026-0495(98)90360-2
DO - 10.1016/S0026-0495(98)90360-2
M3 - Article
C2 - 9712001
AN - SCOPUS:0031880953
VL - 47
SP - 1009
EP - 1035
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
SN - 0026-0495
IS - 8
ER -