Using what is accessible to measure that which is not: Necessity of model of system

Claudio Cobelli, Andrea Caumo

Research output: Contribution to journalArticlepeer-review

Abstract

Understanding the in vivo functioning of endocrine-metabolic systems requires the quantitative knowledge of system parameters like production/utilization of substrates, secretion/degradation of homones, and substrate-hormone signaling. Unfortunately, these system parameters are not directly accessible and an indirect measurement approach is needed based on a model of the system. We review first the principals of the model of system methodology focusing on compartmental and input-output modeling. Then, the model of system methodology is applied to the measurement of nonaccessible parameters/variables of the glucose system like glucose fluxes, insulin fluxes, and glucose-insulin signaling.

Original languageEnglish
Pages (from-to)1009-1035
Number of pages27
JournalMetabolism
Volume47
Issue number8
DOIs
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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