Uterine artery Doppler velocimetry and obstetric outcomes in connective tissue diseases diagnosed during the first trimester of pregnancy

Fausta Beneventi, Elena Locatelli, Véronique Ramoni, Roberto Caporali, Carlo Maurizio Montecucco, Margherita Simonetta, Chiara Cavagnoli, Maria Ferrari, Arsenio Spinillo

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To evaluate the effect of connective tissue disease (CTD) diagnosed during the first trimester on uterine arteries (UtA) Doppler velocities and on pregnancy outcomes. Method: Pregnant women were screened for CTDs during the first trimester, using a questionnaire, testing for autoantibodies, rheumatologic examination and UtA Doppler evaluations. Results: Out of 3932 women screened, 491 (12.5%) were screened positive at the questionnaire; of them, 165(33.6%) tested positive for autoantibodies, including 66 eventually diagnosed with undifferentiated connective tissue disease (UCTD), 28 with a definite CTD and 71 with insufficient criteria for a diagnosis. Controls were 326 women screened negative for autoantibodies. In logistic analysis, women diagnosed with either UCTD (OR=7.9, 95% CI=2.3-27.3) or overt CTD (OR=24.9, 95% CI=6.7-92.4), had increased rates of first trimester bilateral UtA notches compared with controls. The rates of bilateral UtA notches persisting in the second (15/94 vs 0/326, p

Original languageEnglish
Pages (from-to)1094-1101
Number of pages8
JournalPrenatal Diagnosis
Volume32
Issue number11
DOIs
Publication statusPublished - Nov 2012

ASJC Scopus subject areas

  • Genetics(clinical)
  • Obstetrics and Gynaecology

Fingerprint Dive into the research topics of 'Uterine artery Doppler velocimetry and obstetric outcomes in connective tissue diseases diagnosed during the first trimester of pregnancy'. Together they form a unique fingerprint.

Cite this