Tamoxifen used for adjuvant therapy in breast cancer, has a complex and unclear action on endometrium and myometrium. Many authors demonstrated endometrial proliferous changes in peri and post-menopausal women. Our study shows the development of myomas in three patients without uterine pathology before tamoxifen therapy, and the increase of a polip and a myoma after tamoxifen therapy. Moreover, we observed the development of a myoma in a patient after one year tamoxifen in association with LH-RH analogue therapy. It is necessary to continue our study with a larger number of patients to asses the hyperplasic effect of tamoxifen.
|Number of pages||4|
|Journal||Clinical and Experimental Obstetrics and Gynecology|
|Publication status||Published - 1993|
- uterine changes
ASJC Scopus subject areas
- Obstetrics and Gynaecology