Uterine changes during Tamoxifen therapy

S. Rullo, T. Tagliaferri, F. Bandiera, C. Fiorelli, A. Felici, M. G. Piccioni, M. L. Framarino Dei Malatesta

Research output: Contribution to journalArticlepeer-review


Tamoxifen used for adjuvant therapy in breast cancer, has a complex and unclear action on endometrium and myometrium. Many authors demonstrated endometrial proliferous changes in peri and post-menopausal women. Our study shows the development of myomas in three patients without uterine pathology before tamoxifen therapy, and the increase of a polip and a myoma after tamoxifen therapy. Moreover, we observed the development of a myoma in a patient after one year tamoxifen in association with LH-RH analogue therapy. It is necessary to continue our study with a larger number of patients to asses the hyperplasic effect of tamoxifen.

Original languageEnglish
Pages (from-to)116-119
Number of pages4
JournalClinical and Experimental Obstetrics and Gynecology
Issue number2
Publication statusPublished - 1993


  • hysteroscopie
  • tamoxifen
  • uterine changes

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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