Uterine fibroid embolization efficacy and safety: 15 years experience in an elevated turnout rate center

Carmine Di Stasi, Alessandro Cina, Francesco Rosella, Andrea Paladini, Sonia Amoroso, Daniela Romualdi, Riccardo Manfredi, Cesare Colosimo

Research output: Contribution to journalArticlepeer-review


Objective: To evaluate effectiveness and safety of UFE as alternative to surgery, in treatment of uterine fibromatosis. Methods/materials: 255 patients (aged 26–55) with symptomatic UF, indication for surgery, followed in our center (2000–2014), single or multiple fibroids, pain and/or functional/compressive disorders, underwent embolization: injection of PVA particles (150–900 μm) from distal portion of uterine arteries (ascending section). Primary end-point: flow-stop distally to injection site, disappearance of lesion design, preservation of flow in main trunk of UA. Secondary end-point: control of pain and functional/compressive disorders during follow-up (2–7 years). Results: Procedure was performed bilaterally in 250 patients (98%). Mean duration: 47 min (average fluoroscopy: 10:50 min). Post-embolization pelvic pain (according with VAS score) was on average 2.2 at discharge (24 h). Follow-up at 2 years: resolution of menstrual disorders in 78% of patients and improvement in 14%; pain disappeared in 66%; significant improvement of menstrual flow and HCT/HB levels, decrease in total uterine (57.7%)/dominant fibroid (76.1%) volume. Recurrence in 18 patients. Conclusions: UFE represents an excellent alternative to surgical treatment: it is safe, tolerable and effective both in short and long term, with evident advantages in economic and social terms.

Original languageEnglish
Pages (from-to)385-397
Number of pages13
JournalRadiologia Medica
Issue number5
Publication statusPublished - May 1 2018


  • UFE efficacy
  • UFE safety
  • UFE versus surgery
  • Uterine fibroid
  • Uterine fibroid embolization

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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