TY - JOUR
T1 - Uterine fibroid embolization efficacy and safety
T2 - 15 years experience in an elevated turnout rate center
AU - Di Stasi, Carmine
AU - Cina, Alessandro
AU - Rosella, Francesco
AU - Paladini, Andrea
AU - Amoroso, Sonia
AU - Romualdi, Daniela
AU - Manfredi, Riccardo
AU - Colosimo, Cesare
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Objective: To evaluate effectiveness and safety of UFE as alternative to surgery, in treatment of uterine fibromatosis. Methods/materials: 255 patients (aged 26–55) with symptomatic UF, indication for surgery, followed in our center (2000–2014), single or multiple fibroids, pain and/or functional/compressive disorders, underwent embolization: injection of PVA particles (150–900 μm) from distal portion of uterine arteries (ascending section). Primary end-point: flow-stop distally to injection site, disappearance of lesion design, preservation of flow in main trunk of UA. Secondary end-point: control of pain and functional/compressive disorders during follow-up (2–7 years). Results: Procedure was performed bilaterally in 250 patients (98%). Mean duration: 47 min (average fluoroscopy: 10:50 min). Post-embolization pelvic pain (according with VAS score) was on average 2.2 at discharge (24 h). Follow-up at 2 years: resolution of menstrual disorders in 78% of patients and improvement in 14%; pain disappeared in 66%; significant improvement of menstrual flow and HCT/HB levels, decrease in total uterine (57.7%)/dominant fibroid (76.1%) volume. Recurrence in 18 patients. Conclusions: UFE represents an excellent alternative to surgical treatment: it is safe, tolerable and effective both in short and long term, with evident advantages in economic and social terms.
AB - Objective: To evaluate effectiveness and safety of UFE as alternative to surgery, in treatment of uterine fibromatosis. Methods/materials: 255 patients (aged 26–55) with symptomatic UF, indication for surgery, followed in our center (2000–2014), single or multiple fibroids, pain and/or functional/compressive disorders, underwent embolization: injection of PVA particles (150–900 μm) from distal portion of uterine arteries (ascending section). Primary end-point: flow-stop distally to injection site, disappearance of lesion design, preservation of flow in main trunk of UA. Secondary end-point: control of pain and functional/compressive disorders during follow-up (2–7 years). Results: Procedure was performed bilaterally in 250 patients (98%). Mean duration: 47 min (average fluoroscopy: 10:50 min). Post-embolization pelvic pain (according with VAS score) was on average 2.2 at discharge (24 h). Follow-up at 2 years: resolution of menstrual disorders in 78% of patients and improvement in 14%; pain disappeared in 66%; significant improvement of menstrual flow and HCT/HB levels, decrease in total uterine (57.7%)/dominant fibroid (76.1%) volume. Recurrence in 18 patients. Conclusions: UFE represents an excellent alternative to surgical treatment: it is safe, tolerable and effective both in short and long term, with evident advantages in economic and social terms.
KW - UFE efficacy
KW - UFE safety
KW - UFE versus surgery
KW - Uterine fibroid
KW - Uterine fibroid embolization
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U2 - 10.1007/s11547-017-0843-6
DO - 10.1007/s11547-017-0843-6
M3 - Article
C2 - 29357038
AN - SCOPUS:85040798177
VL - 123
SP - 385
EP - 397
JO - Radiologia Medica
JF - Radiologia Medica
SN - 0033-8362
IS - 5
ER -