Uterine papillary serous carcinoma arising in a polyp

A multicenter retrospective analysis on 75 patients

Vincenzo D. Mandato, Federica Torricelli, Stefano Palomba, Stefano Uccella, Debora Pirillo, Gino Ciarlini, Pierandrea De Iaco, Emilio Lucia, Giorgio Giorda, Antonino Ditto, Fabio Ghezzi, Francesca Sanseverino, Massimo Franchi, Giuseppe Bifulco, Valentina Mastrofilippo, Martino Abrate, Lorenzo Aguzzoli, Giovanni B. La Sala

Research output: Contribution to journalArticle

Abstract

Supplemental Digital Content is available in the text.Objectives:The objectives of this study were to evaluate whether the international recommendations on the management of uterine papillary serous carcinoma arising in a polyp are uniformly followed in Italian Oncologic Centers and whether the strategy adopted is effective.Materials and Methods:Patients with uterine papillary serous carcinoma arising in a polyp and who had undergone a hysterectomy were identified in the 2003-2013 database of 7 Italian Gynecologic Oncology Centers. Clinical and pathologic characteristics and outcomes were compared between staging procedure types. Survival curves of the women were plotted using the Kaplan-Meier method and analyzed using Cox regression hazard model and the log-rank test. Associations between clinical parameters and the incidence of recurrence were assessed by generalized linear models and the Fisher test.Results:A total of 75 patients met the inclusion criteria. Recurrence-free survival was affected positively by type of surgical staging and negatively by preoperative diagnosis of hypertension. The association between surgical staging and recurrence-free survival resulted significant at univariate survival analysis (P=0.048 and 0.045) and maintained a trend of significance (P=0.070) in multivariate analysis, whereas hypertension was demonstrated to be the principal influencing factor.Conclusions:The international recommendations on the management of uterine papillary serous carcinoma are not uniformly followed in daily practice, although the extension of the surgery seems to be associated with lower recurrence rates also when uterine papillary serous carcinoma is confined to a polyp or endometrial surface.

Original languageEnglish
Pages (from-to)472-480
Number of pages9
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume42
Issue number5
DOIs
Publication statusPublished - May 1 2019

Fingerprint

Papillary Carcinoma
Polyps
Recurrence
Survival
Hypertension
Survival Analysis
Hysterectomy
Proportional Hazards Models
Linear Models
Multivariate Analysis
Databases
Incidence

Keywords

  • endometrial carcinoma
  • endometrial polyp
  • hypertension
  • recurrence-free survival
  • staging procedures
  • uterine papillary serous carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Uterine papillary serous carcinoma arising in a polyp : A multicenter retrospective analysis on 75 patients. / Mandato, Vincenzo D.; Torricelli, Federica; Palomba, Stefano; Uccella, Stefano; Pirillo, Debora; Ciarlini, Gino; De Iaco, Pierandrea; Lucia, Emilio; Giorda, Giorgio; Ditto, Antonino; Ghezzi, Fabio; Sanseverino, Francesca; Franchi, Massimo; Bifulco, Giuseppe; Mastrofilippo, Valentina; Abrate, Martino; Aguzzoli, Lorenzo; La Sala, Giovanni B.

In: American Journal of Clinical Oncology: Cancer Clinical Trials, Vol. 42, No. 5, 01.05.2019, p. 472-480.

Research output: Contribution to journalArticle

Mandato, VD, Torricelli, F, Palomba, S, Uccella, S, Pirillo, D, Ciarlini, G, De Iaco, P, Lucia, E, Giorda, G, Ditto, A, Ghezzi, F, Sanseverino, F, Franchi, M, Bifulco, G, Mastrofilippo, V, Abrate, M, Aguzzoli, L & La Sala, GB 2019, 'Uterine papillary serous carcinoma arising in a polyp: A multicenter retrospective analysis on 75 patients', American Journal of Clinical Oncology: Cancer Clinical Trials, vol. 42, no. 5, pp. 472-480. https://doi.org/10.1097/COC.0000000000000541
Mandato, Vincenzo D. ; Torricelli, Federica ; Palomba, Stefano ; Uccella, Stefano ; Pirillo, Debora ; Ciarlini, Gino ; De Iaco, Pierandrea ; Lucia, Emilio ; Giorda, Giorgio ; Ditto, Antonino ; Ghezzi, Fabio ; Sanseverino, Francesca ; Franchi, Massimo ; Bifulco, Giuseppe ; Mastrofilippo, Valentina ; Abrate, Martino ; Aguzzoli, Lorenzo ; La Sala, Giovanni B. / Uterine papillary serous carcinoma arising in a polyp : A multicenter retrospective analysis on 75 patients. In: American Journal of Clinical Oncology: Cancer Clinical Trials. 2019 ; Vol. 42, No. 5. pp. 472-480.
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T1 - Uterine papillary serous carcinoma arising in a polyp

T2 - A multicenter retrospective analysis on 75 patients

AU - Mandato, Vincenzo D.

AU - Torricelli, Federica

AU - Palomba, Stefano

AU - Uccella, Stefano

AU - Pirillo, Debora

AU - Ciarlini, Gino

AU - De Iaco, Pierandrea

AU - Lucia, Emilio

AU - Giorda, Giorgio

AU - Ditto, Antonino

AU - Ghezzi, Fabio

AU - Sanseverino, Francesca

AU - Franchi, Massimo

AU - Bifulco, Giuseppe

AU - Mastrofilippo, Valentina

AU - Abrate, Martino

AU - Aguzzoli, Lorenzo

AU - La Sala, Giovanni B.

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Supplemental Digital Content is available in the text.Objectives:The objectives of this study were to evaluate whether the international recommendations on the management of uterine papillary serous carcinoma arising in a polyp are uniformly followed in Italian Oncologic Centers and whether the strategy adopted is effective.Materials and Methods:Patients with uterine papillary serous carcinoma arising in a polyp and who had undergone a hysterectomy were identified in the 2003-2013 database of 7 Italian Gynecologic Oncology Centers. Clinical and pathologic characteristics and outcomes were compared between staging procedure types. Survival curves of the women were plotted using the Kaplan-Meier method and analyzed using Cox regression hazard model and the log-rank test. Associations between clinical parameters and the incidence of recurrence were assessed by generalized linear models and the Fisher test.Results:A total of 75 patients met the inclusion criteria. Recurrence-free survival was affected positively by type of surgical staging and negatively by preoperative diagnosis of hypertension. The association between surgical staging and recurrence-free survival resulted significant at univariate survival analysis (P=0.048 and 0.045) and maintained a trend of significance (P=0.070) in multivariate analysis, whereas hypertension was demonstrated to be the principal influencing factor.Conclusions:The international recommendations on the management of uterine papillary serous carcinoma are not uniformly followed in daily practice, although the extension of the surgery seems to be associated with lower recurrence rates also when uterine papillary serous carcinoma is confined to a polyp or endometrial surface.

AB - Supplemental Digital Content is available in the text.Objectives:The objectives of this study were to evaluate whether the international recommendations on the management of uterine papillary serous carcinoma arising in a polyp are uniformly followed in Italian Oncologic Centers and whether the strategy adopted is effective.Materials and Methods:Patients with uterine papillary serous carcinoma arising in a polyp and who had undergone a hysterectomy were identified in the 2003-2013 database of 7 Italian Gynecologic Oncology Centers. Clinical and pathologic characteristics and outcomes were compared between staging procedure types. Survival curves of the women were plotted using the Kaplan-Meier method and analyzed using Cox regression hazard model and the log-rank test. Associations between clinical parameters and the incidence of recurrence were assessed by generalized linear models and the Fisher test.Results:A total of 75 patients met the inclusion criteria. Recurrence-free survival was affected positively by type of surgical staging and negatively by preoperative diagnosis of hypertension. The association between surgical staging and recurrence-free survival resulted significant at univariate survival analysis (P=0.048 and 0.045) and maintained a trend of significance (P=0.070) in multivariate analysis, whereas hypertension was demonstrated to be the principal influencing factor.Conclusions:The international recommendations on the management of uterine papillary serous carcinoma are not uniformly followed in daily practice, although the extension of the surgery seems to be associated with lower recurrence rates also when uterine papillary serous carcinoma is confined to a polyp or endometrial surface.

KW - endometrial carcinoma

KW - endometrial polyp

KW - hypertension

KW - recurrence-free survival

KW - staging procedures

KW - uterine papillary serous carcinoma

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