Uterine papillary serous carcinoma arising in a polyp: A multicenter retrospective analysis on 75 patients

V.D. Mandato, F. Torricelli, S. Palomba, S. Uccella, D. Pirillo, G. Ciarlini, P. De Iaco, E. Lucia, G. Giorda, A. Ditto, F. Ghezzi, F. Sanseverino, M. Franchi, G. Bifulco, V. Mastrofilippo, M. Abrate, L. Aguzzoli, G.B. La Sala

Research output: Contribution to journalArticle

Abstract

Supplemental Digital Content is available in the text.Objectives:The objectives of this study were to evaluate whether the international recommendations on the management of uterine papillary serous carcinoma arising in a polyp are uniformly followed in Italian Oncologic Centers and whether the strategy adopted is effective.Materials and Methods:Patients with uterine papillary serous carcinoma arising in a polyp and who had undergone a hysterectomy were identified in the 2003-2013 database of 7 Italian Gynecologic Oncology Centers. Clinical and pathologic characteristics and outcomes were compared between staging procedure types. Survival curves of the women were plotted using the Kaplan-Meier method and analyzed using Cox regression hazard model and the log-rank test. Associations between clinical parameters and the incidence of recurrence were assessed by generalized linear models and the Fisher test.Results:A total of 75 patients met the inclusion criteria. Recurrence-free survival was affected positively by type of surgical staging and negatively by preoperative diagnosis of hypertension. The association between surgical staging and recurrence-free survival resulted significant at univariate survival analysis (P=0.048 and 0.045) and maintained a trend of significance (P=0.070) in multivariate analysis, whereas hypertension was demonstrated to be the principal influencing factor.Conclusions:The international recommendations on the management of uterine papillary serous carcinoma are not uniformly followed in daily practice, although the extension of the surgery seems to be associated with lower recurrence rates also when uterine papillary serous carcinoma is confined to a polyp or endometrial surface. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.
Original languageEnglish
Pages (from-to)472-480
Number of pages9
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume42
Issue number5
DOIs
Publication statusPublished - 2019

Keywords

  • adult
  • aged
  • Article
  • cancer staging
  • cohort analysis
  • endometrium carcinoma
  • external beam radiotherapy
  • female
  • histology
  • human
  • hypertension
  • hysterectomy
  • laparoscopy
  • lymph node dissection
  • major clinical study
  • multicenter study
  • omentectomy
  • pelvis lymphadenectomy
  • polyp
  • positron emission tomography
  • preoperative period
  • recurrence free survival
  • recurrence risk
  • retrospective study
  • transvaginal echography
  • very elderly

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