Uterine sarcoma treated by cytoreductive surgery and intraperitoneal hyperthermic perfusion: A feasiblity study

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Abstract

The purpose of this study was to evaluate the feasibility and the outcome impact of cytoreductive surgery (CBS) followed by intraperitoneal hyperthermic perfusion (IPHP) in patients affected by uterine sarcoma (US). Ten US patients were treated with CRS+IPHP (closed technique, cisplatin+mitomycin C or cisplatin+doxorubicin). Median follow-up was 25 months (range: 2-61). Five patients received preoperative chemotherapy. Nine cases underwent optimal CRS. Five-year overall and progression-free survivals were 65% and 30%, respectively. There was no operative morbidity, nor mortality and nor toxicity. Sis patients presented disease progression. CBS+IPHP proved feasible and safe, with encouraging outcome results, warranting confirmation by further prospective controlled trials.

Original languageEnglish
Pages (from-to)19-22
Number of pages4
JournalJournal of Chemotherapy
Volume16
Issue numberSUPPL. 5
Publication statusPublished - Nov 2004

Keywords

  • Peritonectomy and intraperitoneal hyperthermic perfusion
  • Uterine sarcoma

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Microbiology (medical)

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