Uterine vascularization and pregnancy outcome in patients undergoing intracytoplasmatic sperm injection: The role of nitric oxide

C. Battaglia, N. Persico, F. Mancini, P. De Iaco, Paolo Busacchi, F. Facchinetti, D. De Aloysio

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To evaluate whether, after pituitary desensitisation, the impedance to flow in the uterine vessels may be an indicator of an ICSI programme outcome, and to test the relationship between intrafollicular nitric oxide and oocyte/embryo quality. Methods: Thirty-eight women, on the basis of impedance to flow at the level of uterine artery, evaluated on the first day of COH, were divided in patients with normal (Pulsatility Index-PI, ≥2.5; Group I, n=11) and elevated (PI > 2.5; Group II, n=27) PI values. The patients were submitted to hormonal, ultrasonographic and Doppler evaluations. Plasma and follicular fluid concentrations of nitrites/nitrate (NO2 -/NO3 -) were assayed. Results: In the Group I, the impedance to flow remained lower than in Group II and was associated to good quality embryos and to a higher pregnancy rate. Follicular fluid NO 2 -/NO3 - levels were inversely correlated with the embryo quality. The uterine artery PI and the pregnancy rate were inversely correlated. The PIs analysed on the day 1 of stimulation, were positively correlated with those registered on day 8 and on the day of ovum pick-up. Conclusions: A Doppler analysis done on day 1 of controlled ovarian hyperstimulation may be an useful indicator of ART outcome.

Original languageEnglish
Pages (from-to)213-222
Number of pages10
JournalJournal of Assisted Reproduction and Genetics
Volume23
Issue number5
DOIs
Publication statusPublished - May 2006

Keywords

  • Doppler
  • ICSI
  • Nitric oxide
  • Pregnancy rate
  • Ultrasonography

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Developmental Biology
  • Genetics
  • Reproductive Medicine

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