Utility of cerebrospinal fluid cytology in newly diagnosed childhood ependymoma

Lucas Moreno, Ian F. Pollack, Patricia K. Duffner, J. Russell Geyer, Jacques Grill, Maura Massimino, Jonathan L. Finlay, Stergios Zacharoulis

Research output: Contribution to journalArticlepeer-review

Abstract

The role of cytology of cerebrospinal fluid (CSF) has not been established in pediatric ependymoma. Thirty-two children with metastatic ependymoma were analyzed: 11 patients had only positive CSF cytology, 6 had only positive magnetic resonance imaging (MRI) findings, and 15 had both CSF cytology and MRI positive. Twenty-two patients relapsed. Five-year event-free survival was 27.3% ± 13.4% for children with only CSF positive (Ml) versus 26.1% ± 10.2% for patients with positive spine MRI positive (with or without CSF positive, M3) (P = 0.87). In conclusion, 34% of the patients with metastatic ependymoma were identified based on CSF cytology only and their outcome was comparable to patients with macroscopic disease. CSF cytology is a useful tool to stage newly diagnosed patients with ependymoma.

Original languageEnglish
Pages (from-to)515-518
Number of pages4
JournalJournal of Pediatric Hematology/Oncology
Volume32
Issue number6
DOIs
Publication statusPublished - Aug 2010

Keywords

  • CSF cytology
  • Metastatic ependymoma
  • Prognosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology
  • Medicine(all)

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