Utilità della capillaroscopia dinamica computerizzata nella monitorizzazione del trattamento della sclerosi sistemica progressiva con prostacicline di sintesi

The aim of this study was to evaluate the variations of blood flow velocity in the skin microcirculation before and after vasoactive drugs' somministration. Eight patients affected by progressive systemic sclerosis have been treated with synthesis prostacyclin for six hours during a period of fifteen days at the standard dosage of 0.5-2 ng/kg/min. We used computerized dinamic capillaroscopy with Capiflow technique to evaluate cutaneous microcirculation before and after the treatment. The Capiflow technique is a new video-photometric technique to study and quantify the diameter, density and velocity blood flow in the nutritional skin capillary. The quantitative analisys of blood flow velocity detected an increase, statistically significant, at the end of the treatment. The statistic analisys was performed by «t Student» test.