Utility of Gallium-67 in determining the radicality of lymph node dissections of the neck for metastatic lymph nodes with extranodal spread in patients affected by carcinoma of the head and neck

S. Basso Ricci, A. Chiti, R. Molinari, G. Borsa, P. Basso Ricci, S. Villa

Research output: Contribution to journalArticle

Abstract

Aims and background: Based on the fact that scintigraphy more readily reveals uptake of a radioisotope in a superficial position owing to incomplete surgical radicality, the authors examined by 67Ga scintigraphy a group of patients who had undergone dissection of lymph nodes of the neck from carcinoma with extranodal spread. They then checked the follow-up to ascertain the efficacy of 67Ga scintigraphy in relation to the eventual recurrences in the soft tissues of the neck. Methods: A group of 136 patients were examined by 67Ga scintigraphy and followed for a minimum of 3 years after complementary radiotherapy. A group of 20 patients with no lymph node metastases was used as control to evaluate eventual false positives or false negatives. Results: Recurrences in the soft tissues of the neck occurred in 35 (42.7%) of the 82 patients positive at 67Ga scintigraphy and in 6 (11.1%) of the 54 patients negative at the examination (P = 0.0001). All the patients in the control group were negative at 67Ga scintigraphy and without recurrences. Conclusions: 67Ga scintigraphy can give reliable information on the risk of recurrences in the soft tissues of the neck. Since in spite of postoperative radiotherapy the percentage of local recurrences in cases with positive 67Ga scintigraphy was rather high (42.7%), the authors propose a scheme of radiotherapy based on administration of a higher dose per fraction on the scintigraphically positive area.

Original languageEnglish
Pages (from-to)273-276
Number of pages4
JournalTumori
Volume86
Issue number4
Publication statusPublished - 2000

Fingerprint

Gallium
Lymph Node Excision
Radionuclide Imaging
Neck
Lymph Nodes
Head
Carcinoma
Recurrence
Radiotherapy
Radioisotopes
Neoplasm Metastasis
Control Groups

Keywords

  • Gallium-67
  • Head and neck carcinoma
  • Metastatic lymph nodes
  • Radionuclide imaging

ASJC Scopus subject areas

  • Cancer Research

Cite this

Utility of Gallium-67 in determining the radicality of lymph node dissections of the neck for metastatic lymph nodes with extranodal spread in patients affected by carcinoma of the head and neck. / Basso Ricci, S.; Chiti, A.; Molinari, R.; Borsa, G.; Basso Ricci, P.; Villa, S.

In: Tumori, Vol. 86, No. 4, 2000, p. 273-276.

Research output: Contribution to journalArticle

@article{ec29239d3385491bb0faa2abd0c1df42,
title = "Utility of Gallium-67 in determining the radicality of lymph node dissections of the neck for metastatic lymph nodes with extranodal spread in patients affected by carcinoma of the head and neck",
abstract = "Aims and background: Based on the fact that scintigraphy more readily reveals uptake of a radioisotope in a superficial position owing to incomplete surgical radicality, the authors examined by 67Ga scintigraphy a group of patients who had undergone dissection of lymph nodes of the neck from carcinoma with extranodal spread. They then checked the follow-up to ascertain the efficacy of 67Ga scintigraphy in relation to the eventual recurrences in the soft tissues of the neck. Methods: A group of 136 patients were examined by 67Ga scintigraphy and followed for a minimum of 3 years after complementary radiotherapy. A group of 20 patients with no lymph node metastases was used as control to evaluate eventual false positives or false negatives. Results: Recurrences in the soft tissues of the neck occurred in 35 (42.7{\%}) of the 82 patients positive at 67Ga scintigraphy and in 6 (11.1{\%}) of the 54 patients negative at the examination (P = 0.0001). All the patients in the control group were negative at 67Ga scintigraphy and without recurrences. Conclusions: 67Ga scintigraphy can give reliable information on the risk of recurrences in the soft tissues of the neck. Since in spite of postoperative radiotherapy the percentage of local recurrences in cases with positive 67Ga scintigraphy was rather high (42.7{\%}), the authors propose a scheme of radiotherapy based on administration of a higher dose per fraction on the scintigraphically positive area.",
keywords = "Gallium-67, Head and neck carcinoma, Metastatic lymph nodes, Radionuclide imaging",
author = "{Basso Ricci}, S. and A. Chiti and R. Molinari and G. Borsa and {Basso Ricci}, P. and S. Villa",
year = "2000",
language = "English",
volume = "86",
pages = "273--276",
journal = "Tumori",
issn = "0300-8916",
publisher = "SAGE Publications Ltd",
number = "4",

}

TY - JOUR

T1 - Utility of Gallium-67 in determining the radicality of lymph node dissections of the neck for metastatic lymph nodes with extranodal spread in patients affected by carcinoma of the head and neck

AU - Basso Ricci, S.

AU - Chiti, A.

AU - Molinari, R.

AU - Borsa, G.

AU - Basso Ricci, P.

AU - Villa, S.

PY - 2000

Y1 - 2000

N2 - Aims and background: Based on the fact that scintigraphy more readily reveals uptake of a radioisotope in a superficial position owing to incomplete surgical radicality, the authors examined by 67Ga scintigraphy a group of patients who had undergone dissection of lymph nodes of the neck from carcinoma with extranodal spread. They then checked the follow-up to ascertain the efficacy of 67Ga scintigraphy in relation to the eventual recurrences in the soft tissues of the neck. Methods: A group of 136 patients were examined by 67Ga scintigraphy and followed for a minimum of 3 years after complementary radiotherapy. A group of 20 patients with no lymph node metastases was used as control to evaluate eventual false positives or false negatives. Results: Recurrences in the soft tissues of the neck occurred in 35 (42.7%) of the 82 patients positive at 67Ga scintigraphy and in 6 (11.1%) of the 54 patients negative at the examination (P = 0.0001). All the patients in the control group were negative at 67Ga scintigraphy and without recurrences. Conclusions: 67Ga scintigraphy can give reliable information on the risk of recurrences in the soft tissues of the neck. Since in spite of postoperative radiotherapy the percentage of local recurrences in cases with positive 67Ga scintigraphy was rather high (42.7%), the authors propose a scheme of radiotherapy based on administration of a higher dose per fraction on the scintigraphically positive area.

AB - Aims and background: Based on the fact that scintigraphy more readily reveals uptake of a radioisotope in a superficial position owing to incomplete surgical radicality, the authors examined by 67Ga scintigraphy a group of patients who had undergone dissection of lymph nodes of the neck from carcinoma with extranodal spread. They then checked the follow-up to ascertain the efficacy of 67Ga scintigraphy in relation to the eventual recurrences in the soft tissues of the neck. Methods: A group of 136 patients were examined by 67Ga scintigraphy and followed for a minimum of 3 years after complementary radiotherapy. A group of 20 patients with no lymph node metastases was used as control to evaluate eventual false positives or false negatives. Results: Recurrences in the soft tissues of the neck occurred in 35 (42.7%) of the 82 patients positive at 67Ga scintigraphy and in 6 (11.1%) of the 54 patients negative at the examination (P = 0.0001). All the patients in the control group were negative at 67Ga scintigraphy and without recurrences. Conclusions: 67Ga scintigraphy can give reliable information on the risk of recurrences in the soft tissues of the neck. Since in spite of postoperative radiotherapy the percentage of local recurrences in cases with positive 67Ga scintigraphy was rather high (42.7%), the authors propose a scheme of radiotherapy based on administration of a higher dose per fraction on the scintigraphically positive area.

KW - Gallium-67

KW - Head and neck carcinoma

KW - Metastatic lymph nodes

KW - Radionuclide imaging

UR - http://www.scopus.com/inward/record.url?scp=0033840436&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033840436&partnerID=8YFLogxK

M3 - Article

C2 - 11016702

AN - SCOPUS:0033840436

VL - 86

SP - 273

EP - 276

JO - Tumori

JF - Tumori

SN - 0300-8916

IS - 4

ER -